The NIH Blueprint Neurotherapeutics Network (BPN-Biologics) offers this grant to support biologic-based therapeutic discovery and development for disorders of the nervous system. This funding opportunity spans from lead optimization through Phase I clinical testing. It focuses on various Biotechnology Products and Biologics, including large macromolecules, gene-based, cell, and novel emerging therapies. Awardees collaborate with NIH-funded consultants and can augment their projects with specialized NIH Contract Research Organizations (CROs) for manufacturing, pharmacokinetics, toxicology, and Phase I clinical trials. A key feature is that awardee institutions retain their intellectual property rights and gain assignment of IP rights from BPN-Biologics contractors, ensuring control over patent prosecution and licensing.
Opportunity ID: 356611
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-294 |
| Funding Opportunity Title: | Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Environment Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 01, 2024 |
| Last Updated Date: | Oct 01, 2024 |
| Original Closing Date for Applications: | Aug 18, 2027 |
| Current Closing Date for Applications: | Aug 18, 2027 |
| Archive Date: | Sep 23, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue PAR-21-233 – The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-294.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356611 Full Announcement-PAR-24-294 -> PAR-24-294-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288387 | Dec 27, 2024 | Aug 18, 2027 | View |
Package 1
Mandatory forms
356611 RR_SF424_5_0-5.0.pdf
356611 PHS398_CoverPageSupplement_5_0-5.0.pdf
356611 RR_OtherProjectInfo_1_4-1.4.pdf
356611 PerformanceSite_4_0-4.0.pdf
356611 RR_KeyPersonExpanded_4_0-4.0.pdf
356611 RR_Budget_3_0-3.0.pdf
356611 PHS398_ResearchPlan_5_0-5.0.pdf
356611 SBIR_STTR_Information_3_0-3.0.pdf
356611 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356611 RR_SubawardBudget30_3_0-3.0.pdf
356611 PHS_AssignmentRequestForm_4_0-4.0.pdf
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