The National Institutes of Health (NIH) is offering this grant to fund research on the neurological and mental health manifestations of infection-associated chronic illnesses. This grant aims to advance understanding of conditions such as Neuro-PASC, post-treatment Lyme Disease, and ME/CFS. Projects investigating common mechanisms across multiple illnesses are highly encouraged. The scope includes neurologically focused clinical research, basic experimental studies in humans (BESH), mechanistic clinical trials, and preclinical studies using animal, cell, or human tissue models. All proposed research must address a post-infectious etiology to accelerate development of effective treatments.
Opportunity ID: 356747
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-116 |
| Funding Opportunity Title: | Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R01 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 17, 2024 |
| Last Updated Date: | Oct 17, 2024 |
| Original Closing Date for Applications: | Nov 05, 2025 |
| Current Closing Date for Applications: | Nov 05, 2025 |
| Archive Date: | Dec 11, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Small businesses County governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications focused on the neurological and/or mental health-related manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) as well as other chronic illnesses with a potential infectious trigger (post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS], postural orthostatic tachycardia syndrome [POTS], post-viral fatigue syndromes, etc.). Projects that investigate common neurological and/or mental health-related mechanisms across multiple infection-associated chronic illnesses would be of particular interest, although this is not a requirement (i.e., applications can focus on a single condition). Neurologically focused clinical research investigating scientifically compelling pathways that contribute to the development of infection-associated chronic illnesses – including basic experimental studies in humans (BESH) or mechanistic clinical trials that will accelerate the development of effective treatments – are within the scope of this initiative. Preclinical studies utilizing animal, cell culture, and/or human tissue models are also encouraged. All applications must propose such studies in the context of a post-infectious etiology. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-116.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289987 | Jan 11, 2025 | Nov 05, 2025 | View |
Package 1
Mandatory forms
356747 RR_SF424_5_0-5.0.pdf
356747 PHS398_CoverPageSupplement_5_0-5.0.pdf
356747 RR_OtherProjectInfo_1_4-1.4.pdf
356747 PerformanceSite_4_0-4.0.pdf
356747 RR_KeyPersonExpanded_4_0-4.0.pdf
356747 PHS398_ResearchPlan_5_0-5.0.pdf
356747 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356747 RR_Budget_3_0-3.0.pdf
356747 RR_SubawardBudget30_3_0-3.0.pdf
356747 PHS398_ModularBudget_1_2-1.2.pdf
356747 PHS_AssignmentRequestForm_4_0-4.0.pdf
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