This Department of Health grant is for researching the neurological and mental health effects of infection-associated chronic illnesses like Neuro-PASC, post-Lyme Disease, and ME/CFS. It supports investigations into shared mechanisms across conditions, though single-condition focus is permitted. The grant encourages neurologically focused clinical research, including basic experimental studies in humans (BESH) and mechanistic clinical trials to accelerate treatment development. Preclinical studies using animal, cell, or human tissue models are also within scope. All proposed research must explore a post-infectious etiology, aiming to enhance understanding and develop effective treatments for these conditions.
Opportunity ID: 356748
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-115 |
| Funding Opportunity Title: | Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 17, 2024 |
| Last Updated Date: | Oct 17, 2024 |
| Original Closing Date for Applications: | Nov 16, 2025 |
| Current Closing Date for Applications: | Nov 16, 2025 |
| Archive Date: | Dec 22, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities State governments Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications focused on the neurological and/or mental health-related manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) as well as other chronic illnesses with a potential infectious trigger (post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS], postural orthostatic tachycardia syndrome [POTS], post-viral fatigue syndromes, etc.). Projects that investigate common neurological and/or mental health-related mechanisms across multiple infection-associated chronic illnesses would be of particular interest, although this is not a requirement (i.e., applications can focus on a single condition). Neurologically focused clinical research investigating scientifically compelling pathways that contribute to the development of infection-associated chronic illnesses – including basic experimental studies in humans (BESH) or mechanistic clinical trials that will accelerate the development of effective treatments – are within the scope of this initiative. Preclinical studies utilizing animal, cell culture, and/or human tissue models are also encouraged. All applications must propose such studies in the context of a post-infectious etiology. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-115.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356748 Full Announcement-PAR-25-115 -> PAR-25-115-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288416 | Jan 16, 2025 | Nov 16, 2025 | View |
Package 1
Mandatory forms
356748 RR_SF424_5_0-5.0.pdf
356748 PHS398_CoverPageSupplement_5_0-5.0.pdf
356748 RR_OtherProjectInfo_1_4-1.4.pdf
356748 PerformanceSite_4_0-4.0.pdf
356748 RR_KeyPersonExpanded_4_0-4.0.pdf
356748 PHS398_ResearchPlan_5_0-5.0.pdf
356748 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356748 RR_Budget_3_0-3.0.pdf
356748 RR_SubawardBudget30_3_0-3.0.pdf
356748 PHS398_ModularBudget_1_2-1.2.pdf
356748 PHS_AssignmentRequestForm_4_0-4.0.pdf
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