This grant, part of the Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program, is for the purpose of advancing neurotherapeutic discovery through the development and validation of high-relevance model systems. Specifically, it encourages the creation of animal models and human/animal tissue ex vivo systems that accurately replicate the phenotypic and physiologic characteristics of defined neurological or neuromuscular disorders. The primary goal is to significantly enhance the translational applicability of these models for future neurotherapeutic development. Ideal proposals will demonstrate the potential for feasible and meaningful efficacy assessments, bridging preclinical and clinical research, thereby supporting the exploratory and early stages of drug discovery.
Opportunity ID: 356802
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-060 |
| Funding Opportunity Title: | Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 22, 2024 |
| Last Updated Date: | Oct 22, 2024 |
| Original Closing Date for Applications: | Oct 20, 2027 |
| Current Closing Date for Applications: | Oct 20, 2027 |
| Archive Date: | Nov 25, 2027 |
| Estimated Total Program Funding: | $750,000 |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments County governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-060.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356802 Full Announcement-PAR-25-060 -> PAR-25-060-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288420 | Jan 18, 2025 | Oct 20, 2027 | View |
Package 1
Mandatory forms
356802 RR_SF424_5_0-5.0.pdf
356802 PHS398_CoverPageSupplement_5_0-5.0.pdf
356802 RR_OtherProjectInfo_1_4-1.4.pdf
356802 PerformanceSite_4_0-4.0.pdf
356802 RR_KeyPersonExpanded_4_0-4.0.pdf
356802 RR_Budget10_3_0-3.0.pdf
356802 PHS398_ResearchPlan_5_0-5.0.pdf
356802 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356802 RR_SubawardBudget10_30_3_0-3.0.pdf
356802 PHS_AssignmentRequestForm_4_0-4.0.pdf
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