This National Institutes of Health (NIH) grant, structured as a bi-phasic R61/R33 mechanism, is designed to support exploratory and developmental research. Its primary purpose is to identify and optimize small molecules or RNAs that interact with the host’s epigenetic machinery. The ultimate goal is to mediate long-term or permanent epigenetic silencing of HIV-1 proviruses. This funding opportunity encourages innovative projects focused on developing novel strategies to achieve durable suppression of HIV-1 by targeting latent viral reservoirs, aiming for sustained control of infection without the need for continuous antiretroviral therapy. The grant seeks to advance the understanding and therapeutic approaches for lasting HIV-1 inactivation.
Opportunity ID: 293905
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-17-013 |
| Funding Opportunity Title: | Silencing of HIV-1 Proviruses (R61/R33) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | May 17, 2017 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Dec 06, 2017 |
| Current Closing Date for Applications: | Dec 06, 2017 |
| Archive Date: | Jan 11, 2018 |
| Estimated Total Program Funding: | $4,700,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Native American tribal governments (Federally recognized) State governments City or township governments County governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) encourages exploratory and developmental bi-phasic research applications to support the identification and optimization of small molecules or RNAs that interact with host epigenetic machinery to mediate long-term or permanent epigenetic silencing of HIV-1 proviruses |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-17-013.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-D | Use for due dates on or after May 25, 2016 | PKG00232599 | Nov 06, 2017 | Dec 06, 2017 | View |
Package 1
Mandatory forms
293905 RR_SF424_2_0-2.0.pdf
293905 PHS398_CoverPageSupplement_3_0-3.0.pdf
293905 RR_OtherProjectInfo_1_3-1.3.pdf
293905 PerformanceSite_2_0-2.0.pdf
293905 RR_KeyPersonExpanded_2_0-2.0.pdf
293905 RR_Budget_1_3-1.3.pdf
293905 PHS398_ResearchPlan_3_0-3.0.pdf
Optional forms
293905 RR_SubawardBudget30_1_3-1.3.pdf
293905 PHS_Inclusion_Enrollment_Report-1.0.pdf
293905 PHS_AssignmentRequestForm-1.0.pdf
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