This grant is for advancing the quality of animal models in biomedical research. The Office of Research Infrastructure Programs (ORIP) invites applications focused on creating broadly applicable technologies, tools, and resources to enhance rigor, reproducibility, and translatability in animal studies. Proposals should be hypothesis-driven, supported by strong preliminary data, and demonstrate significant impact across diverse research areas utilizing animal models. To align with ORIP’s mission, projects must address interests of multiple NIH Institutes and Centers, explore various organ systems, or apply to diseases impacting multiple systems. The aim is to develop resources that fundamentally improve the reliability and applicability of animal research findings, showcasing how proposed innovations directly enhance study rigor and reproducibility.
Opportunity ID: 356850
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-076 |
| Funding Opportunity Title: | Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.351 — Research Infrastructure Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 25, 2024 |
| Last Updated Date: | Oct 25, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments For profit organizations other than small businesses Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Independent school districts Public housing authorities/Indian housing authorities State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The Office of Research Infrastructure Programs (ORIP) encourages research project grant applications aimed at developing and implementing broadly applicable technologies, tools, and resources for validating animal models and enhancing rigor, reproducibility, and translatability of animal research. Research projects submitted under this Notice of Funding Opportunity (NOFO) should be hypothesis driven with strong preliminary data. Proposed studies, models, resources, or technologies under this NOFO must either address research interests of multiple NIH Institutes and Centers (ICs), explore multiple organ systems, or be applicable to diseases and processes that impact multiple organ systems in order to align with ORIPs NIH-wide mission and programs. Applications should aim to enhance the rigor, reproducibility, and translatability of animal research through the development and implementation of technologies, tools, and resources that have significant impact across a broad range of research areas using animal models. Applications must demonstrate how the proposed resources and technologies impact rigor and reproducibility of animal studies. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-076.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356850 Full Announcement-PAR-25-076 -> PAR-25-076-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288428 | Jan 05, 2025 | Sep 07, 2025 | View |
Package 1
Mandatory forms
356850 RR_SF424_5_0-5.0.pdf
356850 PHS398_CoverPageSupplement_5_0-5.0.pdf
356850 RR_OtherProjectInfo_1_4-1.4.pdf
356850 PerformanceSite_4_0-4.0.pdf
356850 RR_KeyPersonExpanded_4_0-4.0.pdf
356850 PHS398_ResearchPlan_5_0-5.0.pdf
356850 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356850 RR_Budget_3_0-3.0.pdf
356850 RR_SubawardBudget30_3_0-3.0.pdf
356850 PHS398_ModularBudget_1_2-1.2.pdf
356850 PHS_AssignmentRequestForm_4_0-4.0.pdf
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