This grant is for advancing the discovery and early evaluation of promising biomarkers and biomarker signatures for neurological and neuromuscular disorders. Its primary purpose is to identify and initially assess the biological, analytical, and clinical aspects of these biomarkers. They will serve as crucial tools for developing neurotherapeutics and their clinical application. While animal studies are permitted, preliminary human evaluation using standardized samples or datasets is mandatory. The ultimate goal is to deliver robust candidate biomarkers or signatures ready for definitive analytical and clinical validation, accelerating therapeutic progress and improving patient care in this field.
Opportunity ID: 356874
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-024 |
| Funding Opportunity Title: | Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 – Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 28, 2024 |
| Last Updated Date: | Oct 28, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts County governments Public and State controlled institutions of higher education City or township governments For profit organizations other than small businesses State governments Public housing authorities/Indian housing authorities Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-024.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356874 Full Announcement-PAR-25-024 -> PAR-25-024-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288431 | Jan 21, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
356874 RR_SF424_5_0-5.0.pdf
356874 PHS398_CoverPageSupplement_5_0-5.0.pdf
356874 RR_OtherProjectInfo_1_4-1.4.pdf
356874 PerformanceSite_4_0-4.0.pdf
356874 RR_KeyPersonExpanded_4_0-4.0.pdf
356874 RR_Budget10_3_0-3.0.pdf
356874 PHS398_ResearchPlan_5_0-5.0.pdf
356874 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356874 RR_SubawardBudget10_30_3_0-3.0.pdf
356874 PHS_AssignmentRequestForm_4_0-4.0.pdf
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