This grant is for conducting mechanistic investigations into the intricate links between diet, lipid metabolism, and tumor growth and progression. The program aims to support fundamental studies that identify and define the molecular mechanisms through which lipid metabolism mediates tumor development, specifically focusing on how lipids connect diet with the biology of cancer. It seeks to bridge the historically separate fields of nutrition and molecular metabolism, encouraging new research and tool development in this challenging area, given the complexity of lipid biochemistry. This initiative aims to deepen our understanding of these critical biological pathways in cancer, facilitating novel insights into disease mechanisms.
Opportunity ID: 356908
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-118 |
| Funding Opportunity Title: | Mechanistic links between diet, lipid metabolism, and tumor growth and progression (UH2 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 30, 2024 |
| Last Updated Date: | Oct 30, 2024 |
| Original Closing Date for Applications: | Oct 23, 2025 |
| Current Closing Date for Applications: | Oct 23, 2025 |
| Archive Date: | Nov 28, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Small businesses City or township governments Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO) is to request applications that propose mechanistic investigations of the links between diet, lipid metabolism and tumor growth and progression. It is anticipated that this program will support fundamental studies designed to identify and define the molecular mechanisms through which lipid metabolism mediates tumor growth and progression, focusing specifically on the central role lipids play in linking diet with the biology of cancer; bridge the historically divided fields of nutrition and molecular metabolism; and stimulate research and tool development in this emerging area, which faces particular challenges because of the complexity of lipid biochemistry. For this announcement, unpublished preliminary data are limited to one figure, comprising no more than one-half page, to facilitate the entry of qualified new investigators to the field. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-118.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356908 Full Announcement-PAR-25-118 -> PAR-25-118-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288445 | Jan 14, 2025 | Oct 23, 2025 | View |
Package 1
Mandatory forms
356908 RR_SF424_5_0-5.0.pdf
356908 PHS398_CoverPageSupplement_5_0-5.0.pdf
356908 RR_OtherProjectInfo_1_4-1.4.pdf
356908 PerformanceSite_4_0-4.0.pdf
356908 RR_KeyPersonExpanded_4_0-4.0.pdf
356908 PHS398_ResearchPlan_5_0-5.0.pdf
356908 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356908 RR_Budget_3_0-3.0.pdf
356908 RR_SubawardBudget30_3_0-3.0.pdf
356908 PHS398_ModularBudget_1_2-1.2.pdf
356908 PHS_AssignmentRequestForm_4_0-4.0.pdf
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