The National Institutes of Health is offering this grant to advance the functional validation and characterization of genomic variants associated with human congenital anomalies (HCAs). This grant is for researchers to screen and validate genetic variants linked to HCAs, intellectual developmental disabilities (IDDs), and inborn errors of metabolism (IEMs), identified from public databases or individual studies. The initiative addresses a critical gap, promoting use of in-silico tools, animal models, in vitro systems, or multi-pronged approaches to confirm functional effects on relevant phenotypes. Its purpose is to foster deeper understanding beyond mere identification, leveraging increasing genomic data.
Opportunity ID: 356909
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-185 |
| Funding Opportunity Title: | Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 30, 2024 |
| Last Updated Date: | Oct 30, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Native American tribal governments (Federally recognized) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Public and State controlled institutions of higher education State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-185.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356909 Full Announcement-PAR-25-185 -> PAR-25-185-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288446 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
356909 RR_SF424_5_0-5.0.pdf
356909 PHS398_CoverPageSupplement_5_0-5.0.pdf
356909 RR_OtherProjectInfo_1_4-1.4.pdf
356909 PerformanceSite_4_0-4.0.pdf
356909 RR_KeyPersonExpanded_4_0-4.0.pdf
356909 PHS398_ResearchPlan_5_0-5.0.pdf
356909 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356909 RR_Budget_3_0-3.0.pdf
356909 RR_SubawardBudget30_3_0-3.0.pdf
356909 PHS398_ModularBudget_1_2-1.2.pdf
356909 PHS_AssignmentRequestForm_4_0-4.0.pdf
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