This grant from the National Institute of Mental Health (NIMH) is for pilot effectiveness projects aimed at evaluating therapeutic and service delivery interventions for post-acute management of mental health conditions. The trials should assess the feasibility, tolerability, acceptability, safety, and preliminary effectiveness of approaches designed to consolidate gains, manage residual symptoms, prevent relapse, and promote appropriate service use. This funding opportunity supports research to determine if interventions engage their presumed targets and mechanisms, while also gathering essential preliminary data. The findings from these pilot studies will inform the design of larger, definitive effectiveness trials focused on optimizing longer-term outcomes for individuals with mental health conditions. This initiative seeks to advance evidence-based post-acute care.
Opportunity ID: 356923
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-206 |
| Funding Opportunity Title: | Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 31, 2024 |
| Last Updated Date: | Oct 31, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education Private institutions of higher education Small businesses Special district governments Native American tribal governments (Federally recognized) County governments State governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention engages the target(s)/mechanisms(s) that is/are presumed to underlie the intervention effects; and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes. This Notice of Funding Opportunity (NOFO) supports pilot effectiveness research to evaluate the feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches and inform the design of definitive effectiveness trials. Support for fully-powered, definitive effectiveness studies focused on post-acute phase interventions is provided via the R01 currently TEMP-24813. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-206.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356923 Full Announcement-PAR-25-206 -> PAR-25-206-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288341 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
356923 RR_SF424_5_0-5.0.pdf
356923 PHS398_CoverPageSupplement_5_0-5.0.pdf
356923 RR_OtherProjectInfo_1_4-1.4.pdf
356923 PerformanceSite_4_0-4.0.pdf
356923 RR_KeyPersonExpanded_4_0-4.0.pdf
356923 PHS398_ResearchPlan_5_0-5.0.pdf
356923 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356923 RR_Budget_3_0-3.0.pdf
356923 RR_SubawardBudget30_3_0-3.0.pdf
356923 PHS398_ModularBudget_1_2-1.2.pdf
356923 PHS_AssignmentRequestForm_4_0-4.0.pdf
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