The National Institute of Mental Health (NIMH) is offering this grant to support research projects evaluating the effectiveness of therapeutic and service delivery interventions for post-acute management of mental health conditions across youth, adults, and older adults. This grant is specifically for clinical trials establishing the effectiveness of post-acute phase interventions designed to consolidate gains from initial treatment, manage residual symptoms, prevent relapse, and promote adherence for optimal longer-term outcomes. These interventions should be matched to the illness stage in both focus and intensity. The NOFO encourages statistically powered effectiveness trials to provide definitive answers regarding intervention efficacy, building on preliminary findings from companion pilot studies.
Opportunity ID: 356924
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-207 |
| Funding Opportunity Title: | Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 31, 2024 |
| Last Updated Date: | Oct 31, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Public housing authorities/Indian housing authorities State governments City or township governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes. This NOFO is intended to support effectiveness trials testing post-acute phase interventions that are statistically powered to provide a definitive answer regarding the study intervention’s effectiveness. Support for pilot effectiveness trials to evaluate the initial feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches is provided via a companion R34 (Currently TEMP-24814) |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-207.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 356924 Full Announcement-PAR-25-207 -> PAR-25-207-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288342 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
356924 RR_SF424_5_0-5.0.pdf
356924 PHS398_CoverPageSupplement_5_0-5.0.pdf
356924 RR_OtherProjectInfo_1_4-1.4.pdf
356924 PerformanceSite_4_0-4.0.pdf
356924 RR_KeyPersonExpanded_4_0-4.0.pdf
356924 PHS398_ResearchPlan_5_0-5.0.pdf
356924 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
356924 RR_Budget_3_0-3.0.pdf
356924 RR_SubawardBudget30_3_0-3.0.pdf
356924 PHS398_ModularBudget_1_2-1.2.pdf
356924 PHS_AssignmentRequestForm_4_0-4.0.pdf
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