This grant is for advancing research into the intricate epigenetic mechanisms that govern HIV central nervous system (CNS) latency and associated neuropathogenesis. The initiative specifically aims to understand how these mechanisms operate within key brain-derived cells, such as macrophages, microglia, and astrocytes. A central tenet of the funded studies is the innovative application of novel single-cell technologies, facilitating highly detailed and precise investigations into cellular processes. This funding opportunity’s primary purpose is to strongly encourage groundbreaking studies exploring the critical role of epigenetic regulation in HIV CNS latency and the development of neuropathological conditions, thereby fostering a more comprehensive understanding of HIV’s impact on the brain and paving the way for potential therapeutic advancements.
Opportunity ID: 342106
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-22-280 |
| Funding Opportunity Title: | Epigenetic Mechanisms Regulating HIV CNS Latency and Neuropathogenesis Using Novel Single Cell Technologies (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 12, 2022 |
| Last Updated Date: | Jul 12, 2022 |
| Original Closing Date for Applications: | Dec 05, 2022 |
| Current Closing Date for Applications: | Dec 05, 2022 |
| Archive Date: | Jan 10, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments City or township governments Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) Independent school districts Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this initiative is to study the role of epigenetic mechanisms regulating HIV CNS (central nervous system) latency and neuropathogenesis in brain derived cells such as macrophages, microglia and astrocytes using novel single cell technologies. Thus this FOA will encourage studies of the role of epigenetic mechanisms regulating HIV CNS latency and neuropathogenesis in brain derived cells such as macrophages and microglia using novel single cell technologies. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-280.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 342106 Full Announcement-RFA-MH-22-280 -> RFA-MH-22-280-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00275812 | Nov 05, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277891 | Nov 05, 2022 | Dec 05, 2022 | View |
Package 1
Mandatory forms
342106 RR_SF424_5_0-5.0.pdf
342106 PHS398_CoverPageSupplement_5_0-5.0.pdf
342106 RR_OtherProjectInfo_1_4-1.4.pdf
342106 PerformanceSite_4_0-4.0.pdf
342106 RR_KeyPersonExpanded_4_0-4.0.pdf
342106 PHS398_ResearchPlan_4_0-4.0.pdf
342106 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
342106 RR_Budget_3_0-3.0.pdf
342106 RR_SubawardBudget30_3_0-3.0.pdf
342106 PHS398_ModularBudget_1_2-1.2.pdf
342106 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
342106 RR_SF424_5_0-5.0.pdf
342106 PHS398_CoverPageSupplement_5_0-5.0.pdf
342106 RR_OtherProjectInfo_1_4-1.4.pdf
342106 PerformanceSite_4_0-4.0.pdf
342106 RR_KeyPersonExpanded_4_0-4.0.pdf
342106 PHS398_ResearchPlan_5_0-5.0.pdf
342106 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
342106 RR_Budget_3_0-3.0.pdf
342106 RR_SubawardBudget30_3_0-3.0.pdf
342106 PHS398_ModularBudget_1_2-1.2.pdf
342106 PHS_AssignmentRequestForm_3_0-3.0.pdf
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