This Department of Health Research grant is for the purpose of supporting basket clinical trials focused on drugs that target shared molecular etiologies across more than one rare disease. The primary aim of this funding opportunity is to accelerate the development of treatments for complex conditions by allowing a single trial to evaluate a drug’s effectiveness across various rare diseases with common underlying mechanisms. To facilitate rapid clinical trial initiation and leverage existing data, preference will be given to applications that focus on diseases currently under study by the Rare Disease Clinical Research Network (RDCRN) and involve collaborations with RDCRN clinical investigators. This encourages efficient use of established research infrastructure and expertise.
Opportunity ID: 342120
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-TR-22-029 |
| Funding Opportunity Title: | Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.350 — National Center for Advancing Translational Sciences |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jul 13, 2022 |
| Last Updated Date: | Jul 13, 2022 |
| Original Closing Date for Applications: | Jul 12, 2023 |
| Current Closing Date for Applications: | Jul 12, 2023 |
| Archive Date: | Aug 17, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $325,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to support basket clinical trials of drugs targeting shared molecular etiologies in more than one rare disease. To facilitate clinical trial start up, and leverage existing datasets, preference will be given to applications focusing on diseases that are under study by the Rare Disease Clinical Research Network (RDCRN), and that involve collaborations with RDCRN clinical investigators. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-22-029.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 342120 Full Announcement-RFA-TR-22-029 -> RFA-TR-22-029-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00275871 | Jul 18, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278481 | Nov 15, 2022 | Jul 12, 2023 | View |
Package 1
Mandatory forms
342120 RR_SF424_5_0-5.0.pdf
342120 PHS398_CoverPageSupplement_5_0-5.0.pdf
342120 RR_OtherProjectInfo_1_4-1.4.pdf
342120 PerformanceSite_4_0-4.0.pdf
342120 RR_KeyPersonExpanded_4_0-4.0.pdf
342120 RR_Budget_3_0-3.0.pdf
342120 PHS398_ResearchPlan_4_0-4.0.pdf
342120 SBIR_STTR_Information_3_0-3.0.pdf
342120 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
342120 RR_SubawardBudget30_3_0-3.0.pdf
342120 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
342120 RR_SF424_5_0-5.0.pdf
342120 PHS398_CoverPageSupplement_5_0-5.0.pdf
342120 RR_OtherProjectInfo_1_4-1.4.pdf
342120 PerformanceSite_4_0-4.0.pdf
342120 RR_KeyPersonExpanded_4_0-4.0.pdf
342120 RR_Budget_3_0-3.0.pdf
342120 PHS398_ResearchPlan_5_0-5.0.pdf
342120 SBIR_STTR_Information_3_0-3.0.pdf
342120 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
342120 RR_SubawardBudget30_3_0-3.0.pdf
342120 PHS_AssignmentRequestForm_3_0-3.0.pdf
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