The National Cancer Institute (NCI) is offering this grant to expand and improve the utility of mammalian cancer and tumor models for translational research. This grant is for projects demonstrating that these models robustly represent human biology, are appropriate for clinical questions, and provide reliable information for patient benefit. Unlike mechanistic R01 projects, this opportunity emphasizes practical translational applicability. Applicants can propose ways to overcome model deficiencies, define new uses, advance standard practices, or validate/credential models. The NCI aims to foster research that enhances the practical and reliable application of these models in translational oncology, for improved patient outcomes.
Opportunity ID: 357005
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-24-306 |
| Funding Opportunity Title: | Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Sep 07, 2026 |
| Current Closing Date for Applications: | Sep 07, 2026 |
| Archive Date: | Oct 13, 2026 |
| Estimated Total Program Funding: | $499,000 |
| Award Ceiling: | $499,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) For profit organizations other than small businesses State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) City or township governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Private institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients’ benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-24-306.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357005 Full Announcement-PAR-24-306 -> PAR-24-306-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288544 | Jan 05, 2025 | Sep 07, 2026 | View |
Package 1
Mandatory forms
357005 RR_SF424_5_0-5.0.pdf
357005 PHS398_CoverPageSupplement_5_0-5.0.pdf
357005 RR_OtherProjectInfo_1_4-1.4.pdf
357005 PerformanceSite_4_0-4.0.pdf
357005 RR_KeyPersonExpanded_4_0-4.0.pdf
357005 PHS398_ResearchPlan_5_0-5.0.pdf
357005 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357005 RR_Budget_3_0-3.0.pdf
357005 RR_SubawardBudget30_3_0-3.0.pdf
357005 PHS398_ModularBudget_1_2-1.2.pdf
357005 PHS_AssignmentRequestForm_4_0-4.0.pdf
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