The National Institutes of Health (NIH) is offering this grant to encourage research applications focused on developing next-generation human cell-derived microphysiological systems (MPS). This initiative aims to create advanced models that more accurately replicate complex human nervous system architectures and physiological functions compared to current capabilities. This grant is for the purpose of fostering innovative research in biomedical engineering and neuroscience. Supported projects will be instrumental in enabling future studies into the intricate processes of nervous system development, function, and aging, both in healthy individuals and in various disease states. The goal is to provide researchers with more reliable and sophisticated tools to advance understanding and potential therapeutic strategies.
Opportunity ID: 357017
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-198 |
| Funding Opportunity Title: | Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 06, 2024 |
| Last Updated Date: | Nov 06, 2024 |
| Original Closing Date for Applications: | Jan 07, 2026 |
| Current Closing Date for Applications: | Jan 07, 2026 |
| Archive Date: | Feb 12, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses City or township governments Private institutions of higher education State governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-198.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357017 Full Announcement-PAR-25-198 -> PAR-25-198-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288555 | Jan 03, 2025 | Jan 07, 2026 | View |
Package 1
Mandatory forms
357017 RR_SF424_5_0-5.0.pdf
357017 PHS398_CoverPageSupplement_5_0-5.0.pdf
357017 RR_OtherProjectInfo_1_4-1.4.pdf
357017 PerformanceSite_4_0-4.0.pdf
357017 RR_KeyPersonExpanded_4_0-4.0.pdf
357017 PHS398_ResearchPlan_5_0-5.0.pdf
357017 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357017 RR_Budget_3_0-3.0.pdf
357017 RR_SubawardBudget30_3_0-3.0.pdf
357017 PHS398_ModularBudget_1_2-1.2.pdf
357017 PHS_AssignmentRequestForm_4_0-4.0.pdf
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