The National Cancer Institute (NCI) offers this R21 grant to support exploratory projects utilizing bacteria, archaebacteria, bacteriophages, or non-oncolytic viruses and their natural products. This grant is for studying the complex interactions between microorganisms, tumors, and the immune system, and exploring their clinical potential for cancer imaging, therapeutics, or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, immune activators, or delivery vehicles, complementing existing approaches. This funding supports basic mechanistic and preclinical studies in cell culture and animal models, encouraging research into microbial and tumor aspects relevant to therapy, imaging, or diagnosis. It aims to produce breakthroughs in microbial-based cancer solutions.
Opportunity ID: 357071
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-108 |
| Funding Opportunity Title: | Microbial-based Cancer Imaging and Therapy – Bugs as Drugs (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 12, 2024 |
| Last Updated Date: | Nov 12, 2024 |
| Original Closing Date for Applications: | May 07, 2025 |
| Current Closing Date for Applications: | May 07, 2025 |
| Archive Date: | Jun 12, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments County governments City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits grant applications proposing to utilize bacteria, archaebacteria, bacteriophages, or other non-oncolytic viruses and their natural products to study the underlying mechanisms of the complex interactions between microorganisms, tumors, and the immune system, and to explore their clinical potential for cancer imaging, therapeutics or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, as activators of anti-tumor immunity, or as delivery vehicles for treatment, diagnosis, or imaging, complementing or synergizing with existing tools and approaches. This NOFO will support basic mechanistic and preclinical studies in cell culture and animal models. Applicants are encouraged to address both the microbial and tumor aspects of microbial tumor interactions relevant to microbial-based cancer therapy (including therapies for oral cancer), tumor imaging, tumor detection, or diagnosis. The R21 FOA is intended to encourage exploratory projects that are at an early conceptual stage feasibility study (inception through preliminary development) to demonstrate the core functional capabilities of the proposed approach. The proposed projects may involve considerable risk and should be aimed at producing breakthroughs in microbial-based cancer therapy, imaging, or diagnosis. This funding opportunity is part of broader NCI-sponsored research on microbial-based cancer therapy. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-108.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357071 Full Announcement-PAR-25-108 -> PAR-25-108-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288688 | Jan 16, 2025 | May 07, 2025 | View |
Package 1
Mandatory forms
357071 RR_SF424_5_0-5.0.pdf
357071 PHS398_CoverPageSupplement_5_0-5.0.pdf
357071 RR_OtherProjectInfo_1_4-1.4.pdf
357071 PerformanceSite_4_0-4.0.pdf
357071 RR_KeyPersonExpanded_4_0-4.0.pdf
357071 PHS398_ResearchPlan_5_0-5.0.pdf
357071 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357071 RR_Budget_3_0-3.0.pdf
357071 RR_SubawardBudget30_3_0-3.0.pdf
357071 PHS398_ModularBudget_1_2-1.2.pdf
357071 PHS_AssignmentRequestForm_4_0-4.0.pdf
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