This R21 grant opportunity seeks proposals for novel theory and methods development focused on understanding the genetic architecture of complex human traits. The primary objective is to delineate how both genetic and non-genetic factors contribute to trait variation across individuals, families, and diverse populations. Successful approaches will be highly interdisciplinary, spanning natural and social sciences, and will critically account for the intricate interdependencies across biological, social, and ecological organizational scales. Applicants are expected to leverage robust theoretical frameworks, conduct comprehensive simulations, and validate their methodologies using existing large-scale datasets. This initiative aims to significantly advance our comprehension of the multifaceted drivers behind complex human characteristics.
Opportunity ID: 357136
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-256 |
| Funding Opportunity Title: | Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 15, 2024 |
| Last Updated Date: | Nov 15, 2024 |
| Original Closing Date for Applications: | Jan 07, 2027 |
| Current Closing Date for Applications: | Jan 07, 2027 |
| Archive Date: | Feb 12, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses City or township governments County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments Private institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-256.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357136 Full Announcement-PAR-25-256 -> PAR-25-256-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288731 | Jan 16, 2025 | Jan 07, 2027 | View |
Package 1
Mandatory forms
357136 RR_SF424_5_0-5.0.pdf
357136 PHS398_CoverPageSupplement_5_0-5.0.pdf
357136 RR_OtherProjectInfo_1_4-1.4.pdf
357136 PerformanceSite_4_0-4.0.pdf
357136 RR_KeyPersonExpanded_4_0-4.0.pdf
357136 PHS398_ResearchPlan_5_0-5.0.pdf
357136 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357136 RR_Budget_3_0-3.0.pdf
357136 RR_SubawardBudget30_3_0-3.0.pdf
357136 PHS398_ModularBudget_1_2-1.2.pdf
357136 PHS_AssignmentRequestForm_4_0-4.0.pdf
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