This grant supports research into the cellular and molecular biology of high-confidence risk factors associated with complex brain disorders. The focus is on understanding intracellular, transcellular, and circuit substrates of neural function. Projects can be hypothesis-generating or -testing, utilizing various experimental paradigms, including model organisms or human cell-based assays. The aim is to elucidate the neurobiological impact of specific risk factors on molecular and cellular components and their biological processes, not to model entire disorders. Results should be disseminated to common data resources (e.g., Gene Ontology) to bridge the gap between disease risk factors, biological mechanisms, and therapeutic target identification. This R21 opportunity is for early-stage, high-risk, or proof-of-concept studies with limited preliminary data.
Opportunity ID: 357180
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-037 |
| Funding Opportunity Title: | Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 18, 2024 |
| Last Updated Date: | Nov 18, 2024 |
| Original Closing Date for Applications: | Sep 07, 2026 |
| Current Closing Date for Applications: | Sep 07, 2026 |
| Archive Date: | Oct 13, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses County governments Public and State controlled institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts State governments City or township governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components and processes. The resulting paradigms, component pathways and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R21 activity code) can be used for applications to develop early stage, high-risk, exploratory approaches or establish proof-of-concept where there is little or no preliminary data. Applicants proposing to develop lines of inquiry where feasibility or proof of concept has been established should apply to the companion R01 NOFO (PAR-xx-xxx). |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-037.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357180 Full Announcement-PAR-25-037 -> PAR-25-037-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288768 | Jan 16, 2025 | Sep 07, 2026 | View |
Package 1
Mandatory forms
357180 RR_SF424_5_0-5.0.pdf
357180 PHS398_CoverPageSupplement_5_0-5.0.pdf
357180 RR_OtherProjectInfo_1_4-1.4.pdf
357180 PerformanceSite_4_0-4.0.pdf
357180 RR_KeyPersonExpanded_4_0-4.0.pdf
357180 PHS398_ResearchPlan_5_0-5.0.pdf
357180 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357180 RR_Budget_3_0-3.0.pdf
357180 RR_SubawardBudget30_3_0-3.0.pdf
357180 PHS398_ModularBudget_1_2-1.2.pdf
357180 PHS_AssignmentRequestForm_4_0-4.0.pdf
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