This grant, offered by the National Institutes of Health, aims to support critical studies investigating the complex mechanisms through which incretin mimetics—including GLP-1, GIP-1, or dual agents—impact cancer risk. The funding announcement seeks to promote both preclinical and patient-based research, attracting talented scientists to delve into the dynamic, long-term effects of these agents on cancer development. Current data suggests these compounds might concurrently elevate the risk for some obesity-related cancers while potentially reducing the risk for others. The primary objective is to advance understanding of these intricate mechanistic influences on cancer risk, distinguishing this focus from research on shorter-term outcomes like weight loss or diabetes management.
Opportunity ID: 357203
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-070 |
| Funding Opportunity Title: | Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 18, 2024 |
| Last Updated Date: | Nov 18, 2024 |
| Original Closing Date for Applications: | Jan 07, 2027 |
| Current Closing Date for Applications: | Jan 07, 2027 |
| Archive Date: | Feb 12, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses Independent school districts State governments Special district governments Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-070.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357203 Full Announcement-PAR-25-070 -> PAR-25-070-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288792 | Jan 16, 2025 | Jan 07, 2027 | View |
Package 1
Mandatory forms
357203 RR_SF424_5_0-5.0.pdf
357203 PHS398_CoverPageSupplement_5_0-5.0.pdf
357203 RR_OtherProjectInfo_1_4-1.4.pdf
357203 PerformanceSite_4_0-4.0.pdf
357203 RR_KeyPersonExpanded_4_0-4.0.pdf
357203 PHS398_ResearchPlan_5_0-5.0.pdf
357203 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357203 RR_Budget_3_0-3.0.pdf
357203 RR_SubawardBudget30_3_0-3.0.pdf
357203 PHS398_ModularBudget_1_2-1.2.pdf
357203 PHS_AssignmentRequestForm_4_0-4.0.pdf
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