The National Cancer Institute (NCI) is offering this grant to support research into the fundamental biology and underlying mechanisms of bladder cancer. This grant is for addressing the significant medical burden posed by bladder cancer, which has high incidence and frequent recurrence. Despite advancements in molecular profiling, there remains a limited understanding of the molecular mechanisms driving bladder cancer initiation, progression, and malignancy. Furthermore, knowledge about the molecular, cellular, and organ-level processes of the normal bladder is restricted. The NCI aims to fund applications that generate fundamental knowledge on how molecular and cellular functions of the bladder are altered in cancer, thereby aiding in the development of new interventions. Multidisciplinary teams and studies using clinical specimens or investigating both normal and cancerous processes are encouraged.
Opportunity ID: 357251
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-128 |
| Funding Opportunity Title: | Biology of Bladder Cancer (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 20, 2024 |
| Last Updated Date: | Nov 20, 2024 |
| Original Closing Date for Applications: | Sep 07, 2025 |
| Current Closing Date for Applications: | Sep 07, 2025 |
| Archive Date: | Oct 13, 2025 |
| Estimated Total Program Funding: | $200,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Special district governments State governments Independent school districts For profit organizations other than small businesses Small businesses County governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications investigating the biology and underlying mechanisms of bladder cancer. Bladder cancer is a significant health problem both in the United States and globally. Because of the high incidence and frequent tumor recurrence, bladder cancer exacts an outsized medical burden. While recent progress has been made in the molecular profiling of bladder cancers and identification of mutated genes, relatively little is known regarding the molecular mechanisms driving initiation, progression, and malignancy of bladder cancer. Furthermore, our understanding of biological processes of the normal bladder at the molecular, cell and organ levels is limited. Fundamental knowledge of how molecular and cellular functions of the bladder are altered in cancer will aid our understanding of bladder cancer biology and interventions. Applications that involve multidisciplinary teams and use clinical specimens or investigate both normal and cancer processes are encouraged. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-128.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357251 Full Announcement-PAR-25-128 -> PAR-25-128-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288831 | Jan 16, 2025 | Sep 07, 2025 | View |
Package 1
Mandatory forms
357251 RR_SF424_5_0-5.0.pdf
357251 PHS398_CoverPageSupplement_5_0-5.0.pdf
357251 RR_OtherProjectInfo_1_4-1.4.pdf
357251 PerformanceSite_4_0-4.0.pdf
357251 RR_KeyPersonExpanded_4_0-4.0.pdf
357251 PHS398_ResearchPlan_5_0-5.0.pdf
357251 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357251 RR_Budget_3_0-3.0.pdf
357251 RR_SubawardBudget30_3_0-3.0.pdf
357251 PHS398_ModularBudget_1_2-1.2.pdf
357251 PHS_AssignmentRequestForm_4_0-4.0.pdf
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