This grant from NIMH is for understanding the mechanisms of HIV-associated co-morbidities and viral persistence within the Central Nervous System (CNS) despite effective anti-retroviral therapy (ART). Eradicating latent HIV-1 reservoirs is a priority, and the CNS represents a critical challenge. HIV targets the brain early in infection, leading to mild neurological impairments even under ART. This persistence and neuroinflammation are observed despite excellent virologic control. The study will investigate the roles of CD4+ T cells and monocytes in mediating HIV entry, persistence, and neuronal damage. It will also examine CD8+ T cells, which are massively recruited to the CNS to control viral replication. The ultimate goal is to uncover the intricate involvement of T-cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis.
Opportunity ID: 357289
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-26-110 |
| Funding Opportunity Title: | Role of T-Cells in HIV CNS Reservoir Seeding, Persistence, and Neuropathogenesis (R01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 21, 2024 |
| Last Updated Date: | Nov 21, 2024 |
| Original Closing Date for Applications: | Mar 18, 2025 |
| Current Closing Date for Applications: | Mar 18, 2025 |
| Archive Date: | Apr 23, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education County governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Eradicating latent reservoirs of HIV-1 within the body and achieving a sterilizing or functional cure have become priority areas in the AIDS field and NIH AIDS programs across many Institutes and Centers, including NIMH. In addition understanding the mechanisms of HIV- associated co-morbidities in the setting of effective anti-retroviral therapy (ART) is a major topic of interest in the field. HIV Associated CNS (central nervous system) co-morbidities continue to exist despite excellent virologic control in this compartment. HIV persistence and neuroinflammation also continues to observed in the CNS in the setting of ART. HIV targets the CNS early in infection, and HIV-infected individuals suffer from mild forms of neurological impairments even under antiretroviral therapy (ART). CD4+ T cells and monocytes mediate HIV entry into the brain and constitute a source for HIV persistence and neuronal damage. CD8+ T cells are also massively recruited in the CNS in acute infection to control viral replication. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-26-110.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357289 Full Announcement-RFA-MH-26-110 -> RFA-MH-26-110-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288869 | Feb 17, 2025 | Mar 18, 2025 | View |
Package 1
Mandatory forms
357289 RR_SF424_5_0-5.0.pdf
357289 PHS398_CoverPageSupplement_5_0-5.0.pdf
357289 RR_OtherProjectInfo_1_4-1.4.pdf
357289 PerformanceSite_4_0-4.0.pdf
357289 RR_KeyPersonExpanded_4_0-4.0.pdf
357289 PHS398_ResearchPlan_5_0-5.0.pdf
357289 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357289 RR_Budget_3_0-3.0.pdf
357289 RR_SubawardBudget30_3_0-3.0.pdf
357289 PHS398_ModularBudget_1_2-1.2.pdf
357289 PHS_AssignmentRequestForm_4_0-4.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
