The National Heart, Lung, and Blood Institute (NHLBI) is offering this Catalyze Product Definition grant to facilitate the early-stage translation of basic science discoveries into viable diagnostic and therapeutic candidates. This grant is for supporting the identification and characterization of potential therapeutic candidates, including small molecules, biologics, and combination products, to address Heart, Lung, Blood, and Sleep (HLBS) diseases and disorders. The program also aims to develop translational researchers skilled in product development. It provides essential early translational support for projects to meet entry criteria for subsequent preclinical programs, working in conjunction with a companion initiative for device and diagnostic development.
Opportunity ID: 357334
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-26-017 |
| Funding Opportunity Title: | Catalyze: Product Definition for Small Molecules, Biologics and Combination Products – Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.233 — National Center on Sleep Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 22, 2024 |
| Last Updated Date: | Nov 22, 2024 |
| Original Closing Date for Applications: | Dec 23, 2027 |
| Current Closing Date for Applications: | Dec 23, 2027 |
| Archive Date: | Jan 28, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Independent school districts Special district governments For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Product Definition initiative will provide the early stage translational support needed for the activities required to identify and characterize potential therapeutic candidates and combination products to treat HLBS diseases and disorders. This initiative has a companion initiative that supports development of devices and diagnostics and is also part of a suite of innovation grants to advance projects to the point where they can meet the entry criteria for the NHLBI Catalyze Preclinical Program. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-017.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357334 Full Announcement-RFA-HL-26-017 -> RFA-HL-26-017-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288951 | Jan 11, 2025 | Dec 23, 2027 | View |
Package 1
Mandatory forms
357334 RR_SF424_5_0-5.0.pdf
357334 PHS398_CoverPageSupplement_5_0-5.0.pdf
357334 RR_OtherProjectInfo_1_4-1.4.pdf
357334 PerformanceSite_4_0-4.0.pdf
357334 RR_KeyPersonExpanded_4_0-4.0.pdf
357334 RR_Budget10_3_0-3.0.pdf
357334 PHS398_ResearchPlan_5_0-5.0.pdf
357334 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357334 RR_SubawardBudget10_30_3_0-3.0.pdf
357334 PHS_AssignmentRequestForm_4_0-4.0.pdf
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