The Health Research Department is offering this grant to advance translational research focused on understanding the emergence and worsening of mood and psychotic disorders, such as perimenopausal depression, anxiety, bipolar, and schizophrenia, during the menopause transition. This grant is for the purpose of identifying novel targets for future treatment interventions by exploring the underlying neurobiological and behavioral mechanisms of these conditions. It encourages interdisciplinary collaboration and investigates various aspects, including the interplay of classic depressive and menopause symptoms like hot flashes and sleep disturbance, the role of reproductive steroids, diagnostic challenges, co-occurring symptoms, and psychosocial factors common in midlife. The focus is on comprehensive, hypothesis-driven work exploring the mechanisms behind mood and psychosis symptoms.
Opportunity ID: 357341
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-281 |
| Funding Opportunity Title: | Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 22, 2024 |
| Last Updated Date: | Nov 22, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Independent school districts City or township governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the MT. Aspects of mood and psychosis disorders that are of interest include: classic depressive symptoms in combination with menopause symptoms (e.g., hot flashes, night sweats, sleep disturbance) and psychological challenges, the role of reproductive steroids in the regulation of mood and behavior during the MT, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, appreciation of psychosocial factors common in midlife, and differential diagnoses. Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-281.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357341 Full Announcement-PAR-25-281 -> PAR-25-281-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288958 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357341 RR_SF424_5_0-5.0.pdf
357341 PHS398_CoverPageSupplement_5_0-5.0.pdf
357341 RR_OtherProjectInfo_1_4-1.4.pdf
357341 PerformanceSite_4_0-4.0.pdf
357341 RR_KeyPersonExpanded_4_0-4.0.pdf
357341 PHS398_ResearchPlan_5_0-5.0.pdf
357341 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357341 RR_Budget_3_0-3.0.pdf
357341 RR_SubawardBudget30_3_0-3.0.pdf
357341 PHS398_ModularBudget_1_2-1.2.pdf
357341 PHS_AssignmentRequestForm_4_0-4.0.pdf
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