This grant is for the purpose of encouraging invasive neural recording studies in humans to deepen understanding of mental health disorders. It provides an unparalleled opportunity to explore the neural circuitry and dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high precision. Utilizing the same electrodes, researchers can stimulate and test causal relationships by modulating network dynamics. This funding addresses a critical gap in scientific knowledge regarding neural circuit function in mental health conditions. Applicants should focus on specific questions leveraging invasive recording modalities that demonstrate high translational potential, contributing to a clearer picture of brain function related to these disorders. Development of novel technologies or therapies is outside this scope.
Opportunity ID: 357345
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-291 |
| Funding Opportunity Title: | Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 22, 2024 |
| Last Updated Date: | Nov 22, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | $200,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments County governments Special district governments Private institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue of RFA-20-351.The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this NOFO. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-291.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357345 Full Announcement-PAR-25-291 -> PAR-25-291-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00288962 | Jan 16, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357345 RR_SF424_5_0-5.0.pdf
357345 PHS398_CoverPageSupplement_5_0-5.0.pdf
357345 RR_OtherProjectInfo_1_4-1.4.pdf
357345 PerformanceSite_4_0-4.0.pdf
357345 RR_KeyPersonExpanded_4_0-4.0.pdf
357345 PHS398_ResearchPlan_5_0-5.0.pdf
357345 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357345 RR_Budget_3_0-3.0.pdf
357345 RR_SubawardBudget30_3_0-3.0.pdf
357345 PHS398_ModularBudget_1_2-1.2.pdf
357345 PHS_AssignmentRequestForm_4_0-4.0.pdf
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