This NHGRI grant is for establishing Data Analysis and Validation (DAV) Centers for MorPhiC Phase I. MorPhiC’s goal: build a consistent, broadly accessible catalog of molecular and cellular phenotypes for null alleles of every human gene using in vitro systems. Phase I optimizes methods to create and measure effects for 1000 target genes, assesses scalability, develops data formats, and establishes use cases. DAV Centers develop computational models and analysis tools to ensure MorPhiC data’s utility for biomedical community.
Opportunity ID: 343071
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HG-22-019 |
| Funding Opportunity Title: | Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase I: Data Analysis and Validation Centers (U01 Clinical trials not allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 11, 2022 |
| Last Updated Date: | Aug 11, 2022 |
| Original Closing Date for Applications: | Nov 01, 2022 |
| Current Closing Date for Applications: | Nov 01, 2022 |
| Archive Date: | Dec 07, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $350,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses State governments Special district governments Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Data Analysis and Validation (DAV) Centers to join the new NHGRI program called “Molecular Phenotypes of Null Alleles in Cells (MorPhiC)”. The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems. The catalog will be made available for broad use by the biomedical community. The program will start with a Phase 1 to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. Phase 1 will also assess the scale limitations of such methods, develop common data formats, establish use cases for this catalog, and inform whether and how a potential second phase will be implemented. The DAV Centers will develop computational models and data analysis and visualization methods to evaluate and help ensure the utility of the MorPhiC data. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-22-019.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343071 Full Announcement-RFA-HG-22-019 -> RFA-HG-22-019-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00276393 | Oct 01, 2022 | Nov 01, 2022 | View |
Package 1
Mandatory forms
343071 RR_SF424_5_0-5.0.pdf
343071 PHS398_CoverPageSupplement_5_0-5.0.pdf
343071 RR_OtherProjectInfo_1_4-1.4.pdf
343071 PerformanceSite_4_0-4.0.pdf
343071 RR_KeyPersonExpanded_4_0-4.0.pdf
343071 PHS398_ResearchPlan_4_0-4.0.pdf
343071 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343071 RR_Budget_3_0-3.0.pdf
343071 RR_SubawardBudget30_3_0-3.0.pdf
343071 PHS398_ModularBudget_1_2-1.2.pdf
343071 PHS_AssignmentRequestForm_3_0-3.0.pdf
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