The HEAL Initiative offers this R18 grant for the translational development of non-addictive device-based technologies to treat pain. This funding supports creating clinical-grade prototypes for diagnostic and therapeutic interventions, utilizing mechanistic knowledge of pain pathways. The grant’s purpose is to advance new devices to a stage ready for first-in-human (FIH) clinical trials, overcoming preliminary proof-of-concept challenges. Activities include technology development, optimization, and preparing for human use approvals. This grant focuses on pre-clinical advancement, explicitly excluding actual clinical trials, aiming to bring innovative pain solutions to the cusp of human testing.
Opportunity ID: 343213
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-EB-22-002 |
| Funding Opportunity Title: | HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 23, 2022 |
| Last Updated Date: | Apr 16, 2025 |
| Original Closing Date for Applications: | Jun 17, 2025 |
| Current Closing Date for Applications: | Apr 15, 2025 |
| Archive Date: | May 15, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Private institutions of higher education Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this Funding Opportunity Announcement (FOA) is to develop clinical-grade prototypes intended for use as safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-22-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Update close date per NOT-EB-25-001. | Apr 16, 2025 | |
| Aug 23, 2022 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-EB-22-002 |
| Funding Opportunity Title: | HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Aug 23, 2022 |
| Last Updated Date: | Apr 16, 2025 |
| Original Closing Date for Applications: | Jun 17, 2025 |
| Current Closing Date for Applications: | Apr 15, 2025 |
| Archive Date: | May 15, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Private institutions of higher education Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses State governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: |
The purpose of this Funding Opportunity Announcement (FOA) is to develop clinical-grade prototypes intended for use as safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-22-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-EB-22-002 |
| Funding Opportunity Title: | HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 23, 2022 |
| Last Updated Date: | Aug 23, 2022 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Jun 17, 2025 |
| Archive Date: | Jul 23, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $750,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Special district governments Native American tribal governments (Federally recognized) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to develop clinical-grade prototypes intended for use as safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-EB-22-002.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 343213 Full Announcement-RFA-EB-22-002 -> RFA-EB-22-002-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00276514 | Oct 14, 2022 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00277570 | Oct 28, 2022 | Jan 24, 2025 | View | |
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289121 | Nov 26, 2024 | Apr 17, 2025 | View |
Package 1
Mandatory forms
343213 RR_SF424_5_0-5.0.pdf
343213 PHS398_CoverPageSupplement_5_0-5.0.pdf
343213 RR_OtherProjectInfo_1_4-1.4.pdf
343213 PerformanceSite_4_0-4.0.pdf
343213 RR_KeyPersonExpanded_4_0-4.0.pdf
343213 RR_Budget_3_0-3.0.pdf
343213 PHS398_ResearchPlan_4_0-4.0.pdf
343213 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343213 RR_SubawardBudget30_3_0-3.0.pdf
343213 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343213 RR_SF424_5_0-5.0.pdf
343213 PHS398_CoverPageSupplement_5_0-5.0.pdf
343213 RR_OtherProjectInfo_1_4-1.4.pdf
343213 PerformanceSite_4_0-4.0.pdf
343213 RR_KeyPersonExpanded_4_0-4.0.pdf
343213 RR_Budget_3_0-3.0.pdf
343213 PHS398_ResearchPlan_5_0-5.0.pdf
343213 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343213 RR_SubawardBudget30_3_0-3.0.pdf
343213 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 3
Mandatory forms
343213 RR_SF424_5_0-5.0.pdf
343213 PHS398_CoverPageSupplement_5_0-5.0.pdf
343213 RR_OtherProjectInfo_1_4-1.4.pdf
343213 PerformanceSite_4_0-4.0.pdf
343213 RR_KeyPersonExpanded_4_0-4.0.pdf
343213 RR_Budget_3_0-3.0.pdf
343213 PHS398_ResearchPlan_5_0-5.0.pdf
343213 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343213 RR_SubawardBudget30_3_0-3.0.pdf
343213 PHS_AssignmentRequestForm_4_0-4.0.pdf
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