This grant is for advancing the discovery of cellular and molecular mechanisms behind brain blood vessel responses to passive anti-beta-amyloid immunotherapy. Specifically, it aims to understand why amyloid-related imaging abnormalities (ARIA) occur. The ultimate purpose is to identify molecular targets that can safeguard the blood-brain barrier (BBB) and brain blood vessels during therapeutic interventions aimed at beta-amyloid. By delving into these underlying mechanisms, researchers can develop strategies to protect the BBB, ensuring safer and more effective treatments for conditions involving beta-amyloid, ultimately improving patient outcomes by mitigating adverse effects on brain vasculature.
Opportunity ID: 343277
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-22-235 |
| Funding Opportunity Title: | Blood Brain Barrier Response to Antibodies Targeting Beta-Amyloid (R01 – Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Aug 25, 2022 |
| Last Updated Date: | Aug 25, 2022 |
| Original Closing Date for Applications: | Nov 10, 2022 |
| Current Closing Date for Applications: | Nov 10, 2022 |
| Archive Date: | Dec 16, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Private institutions of higher education State governments Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-22-235.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 343277 Full Announcement-PAR-22-235 -> PAR-22-235-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00276575 | Oct 10, 2022 | Nov 10, 2022 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277825 | Nov 01, 2022 | Nov 10, 2022 | View |
Package 1
Mandatory forms
343277 RR_SF424_5_0-5.0.pdf
343277 PHS398_CoverPageSupplement_5_0-5.0.pdf
343277 RR_OtherProjectInfo_1_4-1.4.pdf
343277 PerformanceSite_4_0-4.0.pdf
343277 RR_KeyPersonExpanded_4_0-4.0.pdf
343277 PHS398_ResearchPlan_4_0-4.0.pdf
343277 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343277 RR_Budget_3_0-3.0.pdf
343277 RR_SubawardBudget30_3_0-3.0.pdf
343277 PHS398_ModularBudget_1_2-1.2.pdf
343277 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343277 RR_SF424_5_0-5.0.pdf
343277 PHS398_CoverPageSupplement_5_0-5.0.pdf
343277 RR_OtherProjectInfo_1_4-1.4.pdf
343277 PerformanceSite_4_0-4.0.pdf
343277 RR_KeyPersonExpanded_4_0-4.0.pdf
343277 PHS398_ResearchPlan_5_0-5.0.pdf
343277 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343277 RR_Budget_3_0-3.0.pdf
343277 RR_SubawardBudget30_3_0-3.0.pdf
343277 PHS398_ModularBudget_1_2-1.2.pdf
343277 PHS_AssignmentRequestForm_3_0-3.0.pdf
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