This NIH Research Project Grant is for supporting discrete, investigator-driven basic science experimental studies involving human participants. It specifically targets prospective basic research that, while falling under NIH’s clinical trial definition, aims to understand fundamental phenomena rather than developing specific applications or products. This grant supports studies that experimentally manipulate independent variables in human participants to assess biomedical or behavioral outcomes. Projects should focus on advancing foundational knowledge without immediate translational goals. Furthermore, the proposed research must align with the programmatic interests and scientific missions of one or more participating NIH Institutes and Centers, ensuring relevance to their research portfolios.
Opportunity ID: 357814
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-25-303 |
| Funding Opportunity Title: | NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Environment Food and Nutrition Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Dec 18, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Small businesses For profit organizations other than small businesses Public and State controlled institutions of higher education State governments Independent school districts Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the appropriate Clinical Trials Required or Clinical Trial Optional NOFO. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PA-25-303.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357814 Full Announcement-PA-25-303 -> PA-25-303-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289739 | Jan 05, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357814 RR_SF424_5_0-5.0.pdf
357814 PHS398_CoverPageSupplement_5_0-5.0.pdf
357814 RR_OtherProjectInfo_1_4-1.4.pdf
357814 PerformanceSite_4_0-4.0.pdf
357814 RR_KeyPersonExpanded_4_0-4.0.pdf
357814 PHS398_ResearchPlan_5_0-5.0.pdf
357814 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357814 RR_Budget_3_0-3.0.pdf
357814 RR_SubawardBudget30_3_0-3.0.pdf
357814 PHS398_ModularBudget_1_2-1.2.pdf
357814 PHS_AssignmentRequestForm_4_0-4.0.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
