This grant is for the purpose of supporting research to understand how HIV infection, particularly its effects on immunometabolism in individuals undergoing combination antiretroviral therapy (cART), impacts the immune system and elevates the risk for adverse outcomes from secondary infections such as Tuberculosis (TB) or Hepatitis B Virus (HBV). The funding aims to define precisely how these HIV-induced alterations to immunometabolism influence immune cell regulation, cell-cell interactions, responses to various treatments, and ultimately, the progression of TB and HBV diseases, contributing vital knowledge for disease management.
Opportunity ID: 357822
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-316 |
| Funding Opportunity Title: | Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 18, 2024 |
| Last Updated Date: | Dec 18, 2024 |
| Original Closing Date for Applications: | Jan 07, 2028 |
| Current Closing Date for Applications: | Jan 07, 2028 |
| Archive Date: | Feb 12, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education State governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this notice of funding opportunity (NOFO) is to support research to elucidate how HIV-induced immunometabolic alterations, in a host suppressed on combination antiretroviral therapy (cART-suppressed), impact the immune response and increase risk for poor outcomes due to a second, potentially long-term, infection such as Mycobacterium tuberculosis (Mtb) or Hepatitis B Virus (HBV). This NOFO aims to support research to define how HIV-driven alterations to immunometabolism affect immune cell regulation, cell-cell interactions, response to treatment, and, ultimately, Tuberculosis (TB) and HBV disease progression. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-316.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357822 Full Announcement-PAR-25-316 -> PAR-25-316-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289748 | Apr 07, 2025 | Jan 07, 2028 | View |
Package 1
Mandatory forms
357822 RR_SF424_5_0-5.0.pdf
357822 PHS398_CoverPageSupplement_5_0-5.0.pdf
357822 RR_OtherProjectInfo_1_4-1.4.pdf
357822 PerformanceSite_4_0-4.0.pdf
357822 RR_KeyPersonExpanded_4_0-4.0.pdf
357822 PHS398_ResearchPlan_5_0-5.0.pdf
357822 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357822 RR_Budget_3_0-3.0.pdf
357822 RR_SubawardBudget30_3_0-3.0.pdf
357822 PHS398_ModularBudget_1_2-1.2.pdf
357822 PHS_AssignmentRequestForm_4_0-4.0.pdf
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