This grant, offered by the National Institutes of Health (NIH), is specifically designed to advance research into Alzheimer’s disease (AD) and its related dementias (ADRD). Its primary purpose is to invite innovative applications that propose the development and initial validation of new tests, improved animal models, or novel research techniques. The initiative aims to support methods that currently require additional preliminary data to establish their reliability and broader utility within the scientific community. By funding such foundational work, the grant seeks to facilitate the wider dissemination and general adoption of these cutting-edge tools, thereby significantly accelerating progress in AD/ADRD research. Specific priority research topics will be outlined in subsequent notices.
Opportunity ID: 357936
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-331 |
| Funding Opportunity Title: | Research on Current Topics in Alzheimer’s Disease and Its Related Dementias (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 30, 2024 |
| Last Updated Date: | Jul 03, 2025 |
| Original Closing Date for Applications: | Nov 16, 2027 |
| Current Closing Date for Applications: | Nov 16, 2027 |
| Archive Date: | Dec 22, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education State governments Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications proposing new tests, animal models, techniques, etc. to advance research on Alzheimer’s disease (AD) and its related dementias (ADRD) that need additional preliminary data with broader dissemination to establish them for more general use in this research field. The priority topics will be announced through a series of Notices published subsequent to this NOFO. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-331.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Add ALN/CFDA per NOT-DE-25-046. | Jul 03, 2025 | |
| Dec 30, 2024 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-331 |
| Funding Opportunity Title: | Research on Current Topics in Alzheimer’s Disease and Its Related Dementias (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 30, 2024 |
| Last Updated Date: | Jul 03, 2025 |
| Original Closing Date for Applications: | Nov 16, 2027 |
| Current Closing Date for Applications: | Nov 16, 2027 |
| Archive Date: | Dec 22, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education State governments Independent school districts |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications proposing new tests, animal models, techniques, etc. to advance research on Alzheimer’s disease (AD) and its related dementias (ADRD) that need additional preliminary data with broader dissemination to establish them for more general use in this research field. The priority topics will be announced through a series of Notices published subsequent to this NOFO. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-331.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-331 |
| Funding Opportunity Title: | Research on Current Topics in Alzheimer’s Disease and Its Related Dementias (R21 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 30, 2024 |
| Last Updated Date: | Dec 30, 2024 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Nov 16, 2027 |
| Archive Date: | Dec 22, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) County governments Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Private institutions of higher education Independent school districts State governments City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications proposing new tests, animal models, techniques, etc. to advance research on Alzheimer’s disease (AD) and its related dementias (ADRD) that need additional preliminary data with broader dissemination to establish them for more general use in this research field. The priority topics will be announced through a series of Notices published subsequent to this NOFO. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-331.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Related Documents
Folder 357936 Full Announcement-PAR-25-331 -> PAR-25-331-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289831 | Feb 11, 2025 | Nov 16, 2027 | View |
Package 1
Mandatory forms
357936 RR_SF424_5_0-5.0.pdf
357936 PHS398_CoverPageSupplement_5_0-5.0.pdf
357936 RR_OtherProjectInfo_1_4-1.4.pdf
357936 PerformanceSite_4_0-4.0.pdf
357936 RR_KeyPersonExpanded_4_0-4.0.pdf
357936 PHS398_ResearchPlan_5_0-5.0.pdf
357936 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357936 RR_Budget_3_0-3.0.pdf
357936 RR_SubawardBudget30_3_0-3.0.pdf
357936 PHS398_ModularBudget_1_2-1.2.pdf
357936 PHS_AssignmentRequestForm_4_0-4.0.pdf
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