The National Institutes of Health (NIH) is offering this grant to support research aimed at elucidating the complex mechanisms of early immune system development. This grant is for the purpose of investigating immune development across critical stages: in utero, during the early post-natal period, and throughout early childhood. Studies should focus on neonates, infants, children, and adolescents, including those with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART). Key areas of interest include understanding immune cell functions at the maternal-fetal interface, the intricacies of T and B cell development and maturation in offspring, and the dynamics of both local and systemic immune responses. This initiative seeks to significantly advance our foundational knowledge of the developing immune system from its earliest stages.
Opportunity ID: 357937
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-362 |
| Funding Opportunity Title: | Early Immune System Development and Ontogeny (R01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.865 — Child Health and Human Development Extramural Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 30, 2024 |
| Last Updated Date: | Dec 30, 2024 |
| Original Closing Date for Applications: | Jan 07, 2029 |
| Current Closing Date for Applications: | Jan 07, 2029 |
| Archive Date: | Feb 12, 2029 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $400,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses Independent school districts State governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-362.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 357937 Full Announcement-PAR-25-362 -> PAR-25-362-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289832 | Apr 07, 2025 | Jan 07, 2029 | View |
Package 1
Mandatory forms
357937 RR_SF424_5_0-5.0.pdf
357937 PHS398_CoverPageSupplement_5_0-5.0.pdf
357937 RR_OtherProjectInfo_1_4-1.4.pdf
357937 PerformanceSite_4_0-4.0.pdf
357937 RR_KeyPersonExpanded_4_0-4.0.pdf
357937 PHS398_ResearchPlan_5_0-5.0.pdf
357937 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
357937 RR_Budget_3_0-3.0.pdf
357937 RR_SubawardBudget30_3_0-3.0.pdf
357937 PHS398_ModularBudget_1_2-1.2.pdf
357937 PHS_AssignmentRequestForm_4_0-4.0.pdf
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