The National Institute on Deafness and Other Communication Disorders (NIDCD) offers this grant to support high-risk clinical trials focused on developing advanced in vivo high-resolution imaging technologies for the living human inner ear. This initiative aims to significantly improve current imaging techniques or create new ones, including novel probes and contrast agents, to visualize inner ear structures with unprecedented detail and accuracy. The ultimate goal is enabling non-invasive, detailed visualization of auditory and vestibular components—such as hair cells, otoliths, membranes, ions, and vasculature—in awake patients within a clinical setting. Projects require a multidisciplinary team approach and must propose studies in humans, articulating a clear path for applying the methodology to awake individuals.
Opportunity ID: 358021
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DC-25-003 |
| Funding Opportunity Title: | Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 06, 2025 |
| Last Updated Date: | Jan 06, 2025 |
| Original Closing Date for Applications: | Oct 01, 2026 |
| Current Closing Date for Applications: | Oct 01, 2026 |
| Archive Date: | Nov 06, 2026 |
| Estimated Total Program Funding: | $500,000 |
| Award Ceiling: | $500,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal organizations (other than Federally recognized tribal governments) City or township governments For profit organizations other than small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities State governments Special district governments Native American tribal governments (Federally recognized) Small businesses County governments Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This funding opportunity aims to support high risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. Structural and functional aspects, including visualizing dynamic elements, are important to developing new and improved techniques. Projects may also focus on developing new imaging probes or contrast agents that can enhance visualization of the inner ear structures. Research supported in response to this RFA is expected to significantly advance the ability to visualize auditory and vestibular components, such as hair cells, otoliths, membranes, ions, and vasculature, in detail in awake patients in a clinical setting using non-invasive techniques. To achieve this goal, a multidisciplinary team approach that takes advantage of the expertise of each team member is highly encouraged. Studies in humans must be proposed to develop,advance, or test the needed technology. Any intermediate studies must articulate a clear path of the proposed methodology to application in awake humans or define the limitations and the usefulness in anesthetized humans. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-DC-25-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358021 Full Announcement-RFA-DC-25-003 -> RFA-DC-25-003-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289896 | May 03, 2025 | Oct 01, 2026 | View |
Package 1
Mandatory forms
358021 RR_SF424_5_0-5.0.pdf
358021 PHS398_CoverPageSupplement_5_0-5.0.pdf
358021 RR_OtherProjectInfo_1_4-1.4.pdf
358021 PerformanceSite_4_0-4.0.pdf
358021 RR_KeyPersonExpanded_4_0-4.0.pdf
358021 PHS398_ResearchPlan_5_0-5.0.pdf
358021 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358021 RR_Budget_3_0-3.0.pdf
358021 RR_SubawardBudget30_3_0-3.0.pdf
358021 PHS398_ModularBudget_1_2-1.2.pdf
358021 PHS_AssignmentRequestForm_4_0-4.0.pdf
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