The Defense Advanced Research Projects Agency (DARPA) is offering this grant to fund the development of advanced in vitro platforms, known as Microphysiological Systems. This grant is for the purpose of creating human tissue constructs that can accurately predict the safety, efficacy, and pharmacokinetics of drugs, vaccines, and biologics before human administration. Building on recent advancements in three-dimensional cellular constructs that replicate authentic human physiology, DARPA seeks innovative in vitro systems. These platforms aim to provide reliable human-relevant data for assessing drug effects, toxicity, and pharmacokinetics, ultimately suitable for rigorous regulatory review. The initiative targets a critical need for alternative testing methods that yield more accurate human responses than traditional approaches.
Opportunity ID: 122833
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-11-73 |
| Funding Opportunity Title: | Microphysiological Systems |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Sep 15, 2011 |
| Last Updated Date: | Sep 15, 2011 |
| Original Closing Date for Applications: | Dec 12, 2011 |
| Current Closing Date for Applications: | Dec 12, 2011 |
| Archive Date: | Jan 11, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA seeks an in vitro platform of human tissues that accurately predicts the safety, efficacy, and pharmacokinetics of drugs and vaccines before their administration to humans. Alternative testing methods that rely on isolated human cells hold the promise of authentic human responses to candidate drugs, vaccines, and biologics. Recent research has shown that three-dimensional constructs of one or more cell types are able to reproduce relatively authentic human tissue and organ physiology in an in vitro environment. As a result, DARPA seeks in vitro platforms comprised of human tissue constructs that will accurately assess efficacy, toxicity, and pharmacokinetics in a way that is relevant to humans and suitable for regulatory review. See Attached DARPA-BAA-11-73. |
| Link to Additional Information: | DARPA-BAA-11-73 Modification 1 at FedBizOps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Dr. Barry Palotta
Email:DARPA-BAA-11-73@darpa.mil |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| The purpose of this Modificaiton 1 to DARPA-BAA-11-73 Microphysiological Systems is to update the Closing Date.
The following section is revised as follows: Part One: Overview Information |
Sep 15, 2011 | |
| Sep 15, 2011 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-11-73 |
| Funding Opportunity Title: | Microphysiological Systems |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Sep 15, 2011 |
| Last Updated Date: | Sep 15, 2011 |
| Original Closing Date for Applications: | Dec 12, 2011 |
| Current Closing Date for Applications: | Dec 12, 2011 |
| Archive Date: | Jan 11, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA seeks an in vitro platform of human tissues that accurately predicts the safety, efficacy, and pharmacokinetics of drugs and vaccines before their administration to humans. Alternative testing methods that rely on isolated human cells hold the promise of authentic human responses to candidate drugs, vaccines, and biologics. Recent research has shown that three-dimensional constructs of one or more cell types are able to reproduce relatively authentic human tissue and organ physiology in an in vitro environment. As a result, DARPA seeks in vitro platforms comprised of human tissue constructs that will accurately assess efficacy, toxicity, and pharmacokinetics in a way that is relevant to humans and suitable for regulatory review. See Attached DARPA-BAA-11-73. |
| Link to Additional Information: | DARPA-BAA-11-73 Modification 1 at FedBizOps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Dr. Barry Palotta
Email:DARPA-BAA-11-73@darpa.mil |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | DARPA-BAA-11-73 |
| Funding Opportunity Title: | Microphysiological Systems |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement Other Procurement Contract |
| Category of Funding Activity: | Science and Technology and other Research and Development |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 15, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Dec 12, 2011 |
| Archive Date: | Jan 11, 2012 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility: | – |
Additional Information
| Agency Name: | DARPA – Defense Sciences Office |
| Description: | DARPA seeks an in vitro platform of human tissues that accurately predicts the safety, efficacy, and pharmacokinetics of drugs and vaccines before their administration to humans. Alternative testing methods that rely on isolated human cells hold the promise of authentic human responses to candidate drugs, vaccines, and biologics. Recent research has shown that three-dimensional constructs of one or more cell types are able to reproduce relatively authentic human tissue and organ physiology in an in vitro environment. As a result, DARPA seeks in vitro platforms comprised of human tissue constructs that will accurately assess efficacy, toxicity, and pharmacokinetics in a way that is relevant to humans and suitable for regulatory review. See Attached DARPA-BAA-11-73. |
| Link to Additional Information: | DARPA-BAA-11-73 at FedBizOps |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Dr. Barry Palotta
Email:DARPA-BAA-11-73@darpa.mil |
Related Documents
Folder 122833 Other Supporting Documents-Modification 1 1 -> darpa-baa-11-73 modification 1.pdf
Packages
| Agency Contact Information: | Dr. Barry Palotta Email: DARPA-BAA-11-73@darpa.mil |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 12.910 | PKG00078490 | Sep 15, 2011 | Dec 12, 2011 | View |
Package 1
Mandatory forms
122833 RR_SF424-1.1.pdf
Optional forms
122833 RR_FedNonFedBudget-1.1.pdf
122833 RR_FedNonFed_SubawardBudget-1.2.pdf
122833 RR_OtherProjectInfo-1.1.pdf
122833 RR_Budget-1.1.pdf
122833 RR_KeyPersonExpanded-1.1.pdf
122833 RR_PerformanceSite-1.1.pdf
122833 RR_SubawardBudget-1.2.pdf
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