The HEAL Initiative is offering the Pain Research Enhancement Program (PREP) grant to bolster rigorous basic and mechanistic pain research. This grant is designed to support R15-eligible Principal Investigators (PIs) in conducting essential studies aimed at understanding pain mechanisms. Furthermore, it encourages the formation of integrated, interdisciplinary research partnerships among R15-eligible PIs and other U.S. domestic investigators. A key objective is to significantly enhance the pain research environment at participating R15-eligible institutions. This enhancement is achieved by actively involving health professional trainees, undergraduate, and graduate students in the proposed research projects, fostering a new generation of pain researchers. This initiative aims to advance scientific understanding and expand research capacity in pain management.
Opportunity ID: 358090
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AT-25-003 |
| Funding Opportunity Title: | HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 08, 2025 |
| Last Updated Date: | Jan 08, 2025 |
| Original Closing Date for Applications: | Nov 23, 2026 |
| Current Closing Date for Applications: | Nov 23, 2026 |
| Archive Date: | Dec 29, 2026 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $375,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AT-25-003.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358090 Full Announcement-RFA-AT-25-003 -> RFA-AT-25-003-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289965 | Sep 29, 2025 | Nov 23, 2026 | View |
Package 1
Mandatory forms
358090 RR_SF424_5_0-5.0.pdf
358090 PHS398_CoverPageSupplement_5_0-5.0.pdf
358090 RR_OtherProjectInfo_1_4-1.4.pdf
358090 PerformanceSite_4_0-4.0.pdf
358090 RR_KeyPersonExpanded_4_0-4.0.pdf
358090 PHS398_ResearchPlan_5_0-5.0.pdf
358090 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358090 RR_Budget_3_0-3.0.pdf
358090 RR_SubawardBudget30_3_0-3.0.pdf
358090 PHS398_ModularBudget_1_2-1.2.pdf
358090 PHS_AssignmentRequestForm_4_0-4.0.pdf
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