This grant is for the purpose of establishing and operating an Administrative/Data Coordinating Center (ACC) for the Bench to Bassinet CHANGE Cohort, which focuses on congenital heart disease (CHD) genomics. Evolving from the Pediatric Cardiac Genomics Consortium, the B2B CHANGE Cohort aims to conduct long-term clinical follow-up on participants and perform deeper phenotyping. The ACC will lead data and resource management, sharing, and coordinate critical data collection and participant outreach across clinical sites. This center will also support investigators in securing funding for multi-center, collaborative ancillary studies, aiming to better understand how genetic variants relate to clinical outcomes in CHD, fostering collaboration within the research community.
Opportunity ID: 358120
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-26-007 |
| Funding Opportunity Title: | Single Source: Bench to Bassinet Congenital Heart disease Advancing New understanding in GEnomics Cohort (B2B CHANGE Cohort) Data Coordinating Center (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.837 — Cardiovascular Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 10, 2025 |
| Last Updated Date: | Jan 10, 2025 |
| Original Closing Date for Applications: | Mar 18, 2025 |
| Current Closing Date for Applications: | Mar 18, 2025 |
| Archive Date: | Apr 23, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $4,010,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Only the following applicant is eligible to apply for this single source funding: Cincinnati Children’s Hospital Medical Center. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The B2B Pediatric Cardiac Genomics Consortium (PCGC) (http://www.benchtobassinet.com/) will evolve to the B2B CHANGE Cohort (Congenital Heart disease Advancing New understanding in GEnomics). The B2B CHANGE Cohorts mission will be to conduct long-term clinical follow up on participants from the original PCGC Cohort, to perform deeper cohort phenotyping and to support investigators in applying for funding to conduct multi-center, collaborative ancillary studies to further understand how genetic variants relate to clinical outcomes. The Administrative Coordinating Center (ACC) will serve to lead and advance data and resource management and sharing, and coordinate critical data collection and participant outreach efforts at the clinical research sites. The ACC will work in a collaborative fashion with site PIs, as well as the broader congenital heart disease (CHD) research community. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-007.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358120 Full Announcement-RFA-HL-26-007 -> RFA-HL-26-007-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00289992 | Jan 25, 2025 | Mar 18, 2025 | View |
Package 1
Mandatory forms
358120 RR_SF424_5_0-5.0.pdf
358120 PHS398_CoverPageSupplement_5_0-5.0.pdf
358120 RR_OtherProjectInfo_1_4-1.4.pdf
358120 PerformanceSite_4_0-4.0.pdf
358120 RR_KeyPersonExpanded_4_0-4.0.pdf
358120 RR_Budget10_3_0-3.0.pdf
358120 PHS398_ResearchPlan_5_0-5.0.pdf
358120 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358120 RR_SubawardBudget10_30_3_0-3.0.pdf
358120 PHS_AssignmentRequestForm_4_0-4.0.pdf
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