Department of Defense Grant: Investigator-Initiated Research on Toxic Exposures

The FY22 TERP IIRA is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to toxic exposures. Research projects may focus on any phase of research from basic laboratory research through translational research, including preclinical studies in animal models and human subjects, as well as correlative studies associated with an existing clinical trial. New Approach Methodologies may also be used.

Impact: The application should explicitly state how the proposed research will have a significant impact on toxic exposure research and/or patient care with the intent to transition outcomes into clinical practice for Service Members, Veterans, and/or the American public who have been, or could potentially be, impacted by toxic exposures. State both the short- and long-term impacts and how the proposed research will ultimately lead to new treatments/therapeutics, diagnostic assays, or prevention strategies to improve the quality of life for those that have been impacted by, or are likely to encounter, toxic substances.

Applications should clearly demonstrate the project’s potential near-term and long-term outcome(s)/product(s) (intellectual knowledge and/or tangible materiel) and how they will impact a critical problem or question in the field of research and/or patient care in at least one of the FY22 TERP Program Goals and at least one of the FY22 TERP Topic Areas addressed.

Preliminary data are required. The rationale for a research idea may be derived from laboratory discovery, population-based studies, a clinician’s firsthand knowledge of patients, or anecdotal data. Applications must include relevant preliminary data that support the rationale for the proposed study. These data may be unpublished or from published literature.

Proposed research may be related to diseases, conditions, or symptoms supported by other CDMRP programs; however, TERP applications must be relevant to toxic exposures and be responsive to the FY22 TERP Program Goals and Topic Areas.