This grant, offered by the National Institutes of Health (NIH), aims to accelerate the discovery, preclinical development, and proof-of-concept testing of innovative candidate agents and neurostimulation approaches. The focus is on treating mental disorders, substance use disorders (SUDs), and alcohol use disorder (AUD). Additionally, the initiative supports the development of novel ligands and circuit-engagement devices, crucial as tools for characterizing existing or validating new drug/device targets. Partnerships between academic institutions and industry are highly encouraged to foster collaborative research. This U01 mechanism supports specific, circumscribed projects undertaken by named investigators with relevant expertise, distinct from broader programmatic research.
Opportunity ID: 358229
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-352 |
| Funding Opportunity Title: | National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.242 — Mental Health Research Grants |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 15, 2025 |
| Last Updated Date: | Jan 15, 2025 |
| Original Closing Date for Applications: | Oct 25, 2027 |
| Current Closing Date for Applications: | Oct 25, 2027 |
| Archive Date: | Nov 30, 2027 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Special district governments Small businesses For profit organizations other than small businesses County governments City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-352.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358229 Full Announcement-PAR-25-352 -> PAR-25-352-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00290109 | Jan 25, 2025 | Oct 25, 2027 | View |
Package 1
Mandatory forms
358229 RR_SF424_5_0-5.0.pdf
358229 PHS398_CoverPageSupplement_5_0-5.0.pdf
358229 RR_OtherProjectInfo_1_4-1.4.pdf
358229 PerformanceSite_4_0-4.0.pdf
358229 RR_KeyPersonExpanded_4_0-4.0.pdf
358229 PHS398_ResearchPlan_5_0-5.0.pdf
358229 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358229 RR_Budget_3_0-3.0.pdf
358229 RR_SubawardBudget30_3_0-3.0.pdf
358229 PHS398_ModularBudget_1_2-1.2.pdf
358229 PHS_AssignmentRequestForm_4_0-4.0.pdf
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