This grant is for the purpose of bridging a critical research gap in understanding obligate intracellular human pathogens, including Anaplasma, Ehrlichia, Orientia, and Rickettsia species. Genetic tools for these Rickettsiales currently lag, impeding comprehensive studies and large-scale mutant generation despite recent advances. This funding opportunity directly supports the creation and functional characterization of comprehensive mutant libraries for human-pathogenic rickettsial species. By developing and applying these essential new genetic tools, the grant aims to foster a much deeper understanding of rickettsial pathogen biology, paving the way for future advancements in treating and preventing these infections.
Opportunity ID: 343899
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-22-047 |
| Funding Opportunity Title: | Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 03, 2022 |
| Last Updated Date: | Oct 03, 2022 |
| Original Closing Date for Applications: | Feb 14, 2023 |
| Current Closing Date for Applications: | Feb 14, 2023 |
| Archive Date: | Mar 22, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Small businesses City or township governments Special district governments Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education County governments Native American tribal governments (Federally recognized) Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | A comprehensive understanding of pathogenic bacteriology requires the ability to generate and study genetically altered bacterial strains. For the obligate intracellular human pathogens of the order Rickettsialesincluding Anaplasma, Ehrilichia, Orientia and Rickettsia speciesthese tools have long lagged behind those available for extracellular bacteria. While recent advances have demonstrated the feasibility of genetically manipulating these bacteria, inherent limitations associated with their obligate intracellular nature and reduced genomes have hindered large-scale generation of useful mutants across all species. This funding opportunity will address that research gap by dedicating support to the generation and functional characterization of mutant libraries for rickettsial species that cause infections in humans, and to the application of these new tools to better understanding the biology of rickettsial pathogens. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-22-047.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00277120 | Jan 14, 2023 | Jan 24, 2023 | View | |
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278379 | Jan 14, 2023 | Feb 14, 2023 | View |
Package 1
Mandatory forms
343899 RR_SF424_5_0-5.0.pdf
343899 PHS398_CoverPageSupplement_5_0-5.0.pdf
343899 RR_OtherProjectInfo_1_4-1.4.pdf
343899 PerformanceSite_4_0-4.0.pdf
343899 RR_KeyPersonExpanded_4_0-4.0.pdf
343899 RR_Budget_3_0-3.0.pdf
343899 PHS398_ResearchPlan_4_0-4.0.pdf
343899 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343899 RR_SubawardBudget30_3_0-3.0.pdf
343899 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343899 RR_SF424_5_0-5.0.pdf
343899 PHS398_CoverPageSupplement_5_0-5.0.pdf
343899 RR_OtherProjectInfo_1_4-1.4.pdf
343899 PerformanceSite_4_0-4.0.pdf
343899 RR_KeyPersonExpanded_4_0-4.0.pdf
343899 RR_Budget_3_0-3.0.pdf
343899 PHS398_ResearchPlan_5_0-5.0.pdf
343899 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343899 RR_SubawardBudget30_3_0-3.0.pdf
343899 PHS_AssignmentRequestForm_3_0-3.0.pdf
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