This grant is specifically designed to support groundbreaking research focused on the discovery and development of novel antiviral therapeutics. Its primary purpose is to invite innovative applications aimed at identifying new compounds or strategies capable of eliminating or significantly suppressing Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) within infected cells. Successful proposals will contribute to developing permanent cures for chronic HBV infection by targeting this persistent viral reservoir. This initiative seeks to accelerate the translation of scientific insights into effective treatments, ultimately reducing the global burden of Hepatitis B and preventing its progression to severe liver diseases such as cirrhosis and hepatocellular carcinoma. Applications for clinical trials are not permitted under this specific funding opportunity.
Opportunity ID: 343900
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AI-22-068 |
| Funding Opportunity Title: | Therapeutics for Eliminating Hepatitis B Virus cccDNA (R21/R33 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.855 — Allergy and Infectious Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 03, 2022 |
| Last Updated Date: | Oct 03, 2022 |
| Original Closing Date for Applications: | Feb 14, 2023 |
| Current Closing Date for Applications: | Feb 14, 2023 |
| Archive Date: | Mar 22, 2023 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education City or township governments State governments County governments Public housing authorities/Indian housing authorities Independent school districts Small businesses Special district governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement is to invite applications aimed at discovery of new antivirals that result in the elimination or suppression of HBV ccc DNA from infected cells. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-22-068.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00278380 | Jan 14, 2023 | Feb 14, 2023 | View | |
| FORMS-G | Use for due dates on or before January 24, 2023 | PKG00277121 | Jan 14, 2023 | Jan 24, 2023 | View |
Package 1
Mandatory forms
343900 RR_SF424_5_0-5.0.pdf
343900 PHS398_CoverPageSupplement_5_0-5.0.pdf
343900 RR_OtherProjectInfo_1_4-1.4.pdf
343900 PerformanceSite_4_0-4.0.pdf
343900 RR_KeyPersonExpanded_4_0-4.0.pdf
343900 RR_Budget_3_0-3.0.pdf
343900 PHS398_ResearchPlan_5_0-5.0.pdf
343900 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343900 RR_SubawardBudget30_3_0-3.0.pdf
343900 PHS_AssignmentRequestForm_3_0-3.0.pdf
Package 2
Mandatory forms
343900 RR_SF424_5_0-5.0.pdf
343900 PHS398_CoverPageSupplement_5_0-5.0.pdf
343900 RR_OtherProjectInfo_1_4-1.4.pdf
343900 PerformanceSite_4_0-4.0.pdf
343900 RR_KeyPersonExpanded_4_0-4.0.pdf
343900 RR_Budget_3_0-3.0.pdf
343900 PHS398_ResearchPlan_4_0-4.0.pdf
343900 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
343900 RR_SubawardBudget30_3_0-3.0.pdf
343900 PHS_AssignmentRequestForm_3_0-3.0.pdf
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