This grant, the NIH Directors Pioneer Award Program, is designed to support individual scientists proposing exceptionally creative and bold research projects. Its primary purpose is to fund highly innovative work with the potential for significant impact across broad areas relevant to the NIH mission. As a component of the High-Risk, High-Reward Research Program, this opportunity encourages applications from individuals of diverse backgrounds, including underrepresented groups, and from various institutions nationwide. Research proposals in all scientific fields, such as behavioral, social, biomedical, applied, and formal sciences, are welcome, encompassing basic, translational, or clinical research. The award seeks to foster novel advancements contributing to the vast NIH mission.
Opportunity ID: 358872
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-25-001 |
| Funding Opportunity Title: | NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 13, 2025 |
| Last Updated Date: | Jun 13, 2025 |
| Original Closing Date for Applications: | Sep 09, 2025 |
| Current Closing Date for Applications: | Sep 09, 2025 |
| Archive Date: | Oct 15, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $700,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) County governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The NIH Directors Pioneer Award Program supports individual scientists of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIHs Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Directors Pioneer Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-25-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 358872 Full Announcement-RFA-RM-25-001 -> RFA-RM-25-001-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00290964 | Aug 09, 2025 | Sep 09, 2025 | View |
Package 1
Mandatory forms
358872 RR_SF424_5_0-5.0.pdf
358872 PerformanceSite_4_0-4.0.pdf
358872 RR_OtherProjectInfo_1_4-1.4.pdf
358872 RR_KeyPersonExpanded_4_0-4.0.pdf
358872 PHS398_CoverPageSupplement_5_0-5.0.pdf
358872 PHS398_ResearchPlan_5_0-5.0.pdf
358872 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
358872 PHS_AssignmentRequestForm_4_0-4.0.pdf
358872 RR_Budget10_3_0-3.0.pdf
358872 RR_SubawardBudget10_30_3_0-3.0.pdf
358872 PHS398_ModularBudget_1_2-1.2.pdf
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