Opportunity ID: 131893
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-RM-12-001 |
| Funding Opportunity Title: | Stem/Progenitor Cell-Derived Human Micro-organs and -tissues (U18) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.310 — Trans-NIH Research Support |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Nov 23, 2011 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 26, 2012 |
| Current Closing Date for Applications: | Jan 26, 2012 |
| Archive Date: | Feb 26, 2012 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $250,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: For a Diversity FOA that restricts eligibility by targeting diverse institutions, insert standard Diversity language regarding eligible institutions here. (see Lisa Evans,OER). Note that FOAs can target institutions or individuals but not both. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This NIH Funding Opportunity Announcement (FOA), supported by funds from the NIH Common Fund (Common Fund) and participating NIH Institute(s) and Center(s), invites applications for the development of human multi-cellular models that can replicate aspects of human organ physiology. Disease pathogenesis, cell-type diversity, genomic complexity, monitoring of cell to cell and cell to matrix interactions and microenvironment regulation are key aspects to be addressed by these model systems. The multi-cellular architecture will represent characteristics of the organ being modeled and will demonstrate reproducible cellular signatures and functional outputs under physiological conditions. It is anticipated that these human cell/tissue models could lead to the development and commercialization of cellular 3D modules that would eventually become part of larger organ systems targeted for rapid and high fidelity safety and efficacy evaluation of candidate therapeutics.
Applications unresponsive to this FOA are those developing 3D tissues for transplantation, engineering non-human tissue models or developing simple 3D models that do not go significantly beyond those currently available and in use. Funds from the NIH will be made available through the U18 cooperative agreement award mechanism. These 2 year awards will support studies to develop multi-cellular models representative of the cellular diversity, genomic complexity, cellular architecture and function of the tissues or organs being modeled.Multi-cellular models that reflect disease pathologies including but not limited to cardiomyopathy, endocrinopathies, type 1 and type 2 diabetes, inflammatory bowel disease, pancreatitis, autoimmunity, fibrosis, muscular dystrophies, neuromuscular disorders, neurodevelopmental disorders, seizures, pulmonary hypertension and cystic fibrosis are of particular interest. The NIH is collaborating with the Defense Advanced Research Projects Agency (DARPA) and the US Food and Drug Administration (FDA) to enable coordination of separate but parallel efforts in development of in vitro microphysiological systems as they relate to regulatory science. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-001.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.310 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00086650 | Dec 26, 2011 | Jan 26, 2012 | View |
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