This funding opportunity from the Health Research Department is for exploratory and early-stage projects focused on undruggable target classes within intractable human diseases. This grant is for the purpose of identifying human disease-relevant undruggable targets and developing innovative methods or agents selective for them. Applicants are expected to propose strategies to modulate targets currently unaddressed by established therapeutic types. The goal is to jumpstart research that demonstrates groundbreaking approaches, furthering the development of new methods and/or agents specifically designed for these challenging undruggable target classes. This initiative aims to significantly expand the therapeutic landscape for complex human diseases.
Opportunity ID: 359154
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PAR-25-442 |
| Funding Opportunity Title: | Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jun 17, 2025 |
| Last Updated Date: | Jun 17, 2025 |
| Original Closing Date for Applications: | Feb 17, 2028 |
| Current Closing Date for Applications: | Feb 17, 2028 |
| Archive Date: | Mar 24, 2028 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments City or township governments County governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/pa-files/PAR-25-442.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 359154 Full Announcement-PAR-25-442 -> PAR-25-442-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-I | Use for due dates on or after January 25, 2025 | PKG00290979 | Sep 17, 2025 | Feb 17, 2028 | View |
Package 1
Mandatory forms
359154 RR_SF424_5_0-5.0.pdf
359154 PHS398_CoverPageSupplement_5_0-5.0.pdf
359154 RR_OtherProjectInfo_1_4-1.4.pdf
359154 PerformanceSite_4_0-4.0.pdf
359154 RR_KeyPersonExpanded_4_0-4.0.pdf
359154 PHS398_ResearchPlan_5_0-5.0.pdf
359154 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
359154 RR_Budget_3_0-3.0.pdf
359154 RR_SubawardBudget30_3_0-3.0.pdf
359154 PHS398_ModularBudget_1_2-1.2.pdf
359154 PHS_AssignmentRequestForm_4_0-4.0.pdf
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