Opportunity ID: 362062
General Information
| Funding Opportunity Number | PD-26-369Y |
| Funding Opportunity Title | Engineering Biological and Biomedical Systems (EBBS) |
| Agency | U.S. National Science Foundation |
| Document Type | synopsis |
| Version | 2 |
| Opportunity Category | Discretionary |
| Opportunity Category Explanation | Not specified |
| Funding Instrument Type | Grant |
| Category of Funding Activity | Science and Technology and other Research and Development |
| Category Explanation | Not specified |
| Expected Number of Awards | Not specified |
| Cost Sharing or Matching Requirement | No |
| Posted Date | Apr 24, 2026 12:00:00 AM EDT |
| Last Updated Date | Apr 27, 2026 11:00:13 PM EDT |
| Original Closing Date | Not specified |
| Original Closing Date Notes | Proposals accepted anytime |
| Current Closing Date | Not specified |
| Current Closing Date Notes | Proposals accepted anytime |
| Estimated Synopsis Date | Not specified |
| Estimated Application Due Date | Not specified |
| Estimated Award Date | Not specified |
| Estimated Project Start Date | Not specified |
| Archive Date | Not specified |
| Estimated Total Program Funding | Not specified |
| Award Ceiling | none |
| Award Floor | none |
Assistance Listings
- 47.041 — Engineering
- —
Eligibility
| Eligible Applicants | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility" |
Description
The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. Engineering is needed for sensing biomarkers to making proteins to restoring functions of the body. In EBBS, fundamental mechanistic insights are combined with experimental and computational techniques. This approach helps develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological functions.
EBBS supports studies of mechanisms that drive the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to capture the responses of biological systems and bioreactors. It also includes the creation of novel biosensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the functions of tissues or organs are encouraged.
Projects that advance rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged.
The EBBS program expands what is possible in biomanufacturing; research may advance biotechnology and/or health. EBBS research must enable improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes.
EBBS does not support proposals with a main goal of drug design, drug delivery, or the development of animal models of disease. Using existing models for experimental testing and validation is acceptable. Projects that focus on testing and validating therapies are not supported. Clinical trials are not supported. Limited studies involving human volunteers may be supported if appropriate to the project objectives. Projects focused on commercialization are more appropriate for the NSF Directorate for Technology, Innovation, and Partnerships (TIP).
Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships.
Additional Information
| Contact | U.S. National Science Foundation |
| Contact Information | NSF support grantsgovsupport@nsf.gov |
| grantsgovsupport@nsf.gov | |
| Email Description | If you have any problems linking to this funding announcement, please contact the email address above. |
| Phone | 703-292-4203 |
NSF Program Desccription PD-26-369Y
Version History
Version history
| Opp hist id / Opportunity id | 362062 |
| Opp hist id / Revision | 0 |
| Opportunity id | 362062 |
| Revision | 0 |
| Opportunity number | PD-26-369Y |
| Opportunity title | Engineering Biological and Biomedical Systems (EBBS) |
| Owning agency code | NSF |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Synopsis / Id / Opportunity id | 362062 |
| Synopsis / Id / Revision | 0 |
| Synopsis / Opportunity id | 362062 |
| Synopsis / Revision | 0 |
| Synopsis / Version | 1 |
| Synopsis / Agency code | NSF |
| Synopsis / Agency address desc | If you have any problems linking to this funding announcement, please contact the email address above. |
| Synopsis / Agency details / Code | NSF |
| Synopsis / Agency details / Seed | NSF |
| Synopsis / Agency details / Agency name | U.S. National Science Foundation |
| Synopsis / Agency details / Agency code | NSF |
| Synopsis / Agency details / Top agency code | NSF |
| Synopsis / Agency contact phone | 703-292-4203 |
| Synopsis / Agency contact name | U.S. National Science Foundation |
| Synopsis / Agency contact desc | NSF support grantsgovsupport@nsf.gov |
| Synopsis / Agency contact email | grantsgovsupport@nsf.gov |
| Synopsis / Agency contact email desc | If you have any problems linking to this funding announcement, please contact the email address above. |
| Synopsis / Synopsis desc | TheEngineering Biological and Biomedical Systems(EBBS)program expandsour understanding of biological and physiological systems,andithelpsimprove humanhealth.ForU.S.leadershipin biotechnology,theengineeringofbiologyisrequiredat every scale.Engineering is needed forsensingbiomarkerstomakingproteinsto restoring functions of the body.InEBBS,fundamentalmechanistic insightsarecombinedwith experimental and computational techniques.Thisapproachhelpsdevelopplatforms, devices, organisms, tissues,andprocesses thatbringnewunderstanding and control of biological functions.
EBBSsupportsstudies of mechanismsthatdrivethe behavior of microbial populations and cells,and of therapeutic cells and tissues.This includes discovering theunderlying engineering principlesthat are needed tocapturethe responses of biological systems and bioreactors.It alsoincludesthecreationofnovelbiosensing platformsandnew optical imaging and modulation strategies.Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight intotissuechangesor injury,andtosystems thatimitateor restorethefunctionsoftissuesororgans areencouraged. Projects thatadvancerehabilitation engineeringthrough new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by theneeds of persons with disabilitiesis encouraged. The EBBS programexpandswhat is possible inbiomanufacturing;researchmayadvancebiotechnology and/orhealth.EBBSresearchmustenableimprovedbiological processes,createnovelbiomedical technologies, orachievenewunderstanding of physiological or pathological processes. EBBSdoesnot support proposalswithamaingoal ofdrug design,drugdelivery, or the development of animal models of disease.Usingexisting models for experimental testing and validation is acceptable. Projectsthatfocus ontesting andvalidatingtherapiesare not supported.Clinical trials are not supported.Limitedstudies involving human volunteers may be supported ifappropriate tothe projectobjectives. Projects focused on commercialization are moreappropriate fortheNSFDirectorate for Technology, Innovation, and Partnerships (TIP). Partnerships:Tospeeddiscovery and innovation, NSF partners with federal agencies, industry, internationalgroups, and others. Current opportunities are atNSF ENG Partnerships. |
| Synopsis / Response date desc | Proposals accepted anytime |
| Synopsis / Funding desc link url | http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=506548 |
| Synopsis / Funding desc link desc | NSF Program Desccription PD-26-369Y |
| Synopsis / Posting date | Apr 24, 2026 12:00:00 AM EDT |
| Synopsis / Cost sharing | No |
| Synopsis / Award ceiling | none |
| Synopsis / Award floor | none |
| Synopsis / Create time stamp | Apr 24, 2026 11:00:08 PM EDT |
| Synopsis / Action type | U |
| Synopsis / Action date | Apr 27, 2026 11:00:13 PM EDT |
| Synopsis / Created date | Apr 24, 2026 11:00:08 PM EDT |
| Synopsis / Last updated date | Apr 24, 2026 11:00:08 PM EDT |
| Synopsis / Applicant types 1 / Id | 99 |
| Synopsis / Applicant types 1 / Description | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility" |
| Synopsis / Funding instruments 1 / Id | G |
| Synopsis / Funding instruments 1 / Description | Grant |
| Synopsis / Funding activity categories 1 / Id | ST |
| Synopsis / Funding activity categories 1 / Description | Science and Technology and other Research and Development |
| Synopsis / Posting date str | 2026-04-24-00-00-00 |
| Synopsis / Create time stamp str | 2026-04-24-23-00-08 |
| Cfdas 1 / Id | 432893 |
| Cfdas 1 / Opportunity id | 362062 |
| Cfdas 1 / Revision | 0 |
| Cfdas 1 / Cfda number | 47.041 |
| Cfdas 1 / Program title | Engineering |
| Cfdas 2 / Id | 432897 |
| Cfdas 2 / Opportunity id | 362062 |
| Cfdas 2 / Revision | 0 |
| Synopsis modified fields | Not specified |
| Forecast modified fields | Not specified |
Synopsis changes
revision
version
synopsisDesc
createTimeStamp
| Id | 362062 |
| Revision | 1 |
| Opportunity number | PD-26-369Y |
| Opportunity title | Engineering Biological and Biomedical Systems (EBBS) |
| Owning agency code | NSF |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Synopsis / Opportunity id | 362062 |
| Synopsis / Version | 2 |
| Synopsis / Agency code | NSF |
| Synopsis / Agency name | U.S. National Science Foundation |
| Synopsis / Agency phone | 703-292-4203 |
| Synopsis / Agency address desc | If you have any problems linking to this funding announcement, please contact the email address above. |
| Synopsis / Agency details / Code | NSF |
| Synopsis / Agency details / Seed | NSF |
| Synopsis / Agency details / Agency name | U.S. National Science Foundation |
| Synopsis / Agency details / Agency code | NSF |
| Synopsis / Agency details / Top agency code | NSF |
| Synopsis / Top agency details / Code | NSF |
| Synopsis / Top agency details / Seed | NSF |
| Synopsis / Top agency details / Agency name | U.S. National Science Foundation |
| Synopsis / Top agency details / Agency code | NSF |
| Synopsis / Top agency details / Top agency code | NSF |
| Synopsis / Agency contact phone | 703-292-4203 |
| Synopsis / Agency contact name | U.S. National Science Foundation |
| Synopsis / Agency contact desc | NSF support grantsgovsupport@nsf.gov |
| Synopsis / Agency contact email | grantsgovsupport@nsf.gov |
| Synopsis / Agency contact email desc | If you have any problems linking to this funding announcement, please contact the email address above. |
| Synopsis / Synopsis desc | The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. Engineering is needed for sensing biomarkers to making proteins to restoring functions of the body. In EBBS, fundamental mechanistic insights are combined with experimental and computational techniques. This approach helps develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological functions.
EBBS supports studies of mechanisms that drive the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to capture the responses of biological systems and bioreactors. It also includes the creation of novel biosensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the functions of tissues or organs are encouraged. Projects that advance rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged. The EBBS program expands what is possible in biomanufacturing; research may advance biotechnology and/or health. EBBS research must enable improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes. EBBS does not support proposals with a main goal of drug design, drug delivery, or the development of animal models of disease. Using existing models for experimental testing and validation is acceptable. Projects that focus on testing and validating therapies are not supported. Clinical trials are not supported. Limited studies involving human volunteers may be supported if appropriate to the project objectives. Projects focused on commercialization are more appropriate for the NSF Directorate for Technology, Innovation, and Partnerships (TIP). Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships. |
| Synopsis / Response date desc | Proposals accepted anytime |
| Synopsis / Funding desc link url | http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=506548 |
| Synopsis / Funding desc link desc | NSF Program Desccription PD-26-369Y |
| Synopsis / Posting date | Apr 24, 2026 12:00:00 AM EDT |
| Synopsis / Cost sharing | No |
| Synopsis / Award ceiling | none |
| Synopsis / Award floor | none |
| Synopsis / Create time stamp | Apr 27, 2026 11:00:13 PM EDT |
| Synopsis / Mod comments | . |
| Synopsis / Created date | Apr 24, 2026 11:00:08 PM EDT |
| Synopsis / Last updated date | Apr 27, 2026 11:00:13 PM EDT |
| Synopsis / Applicant types 1 / Id | 99 |
| Synopsis / Applicant types 1 / Description | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility" |
| Synopsis / Funding instruments 1 / Id | G |
| Synopsis / Funding instruments 1 / Description | Grant |
| Synopsis / Funding activity categories 1 / Id | ST |
| Synopsis / Funding activity categories 1 / Description | Science and Technology and other Research and Development |
| Synopsis / Posting date str | 2026-04-24-00-00-00 |
| Synopsis / Create time stamp str | 2026-04-27-23-00-13 |
| Agency details / Code | NSF |
| Agency details / Seed | NSF |
| Agency details / Agency name | U.S. National Science Foundation |
| Agency details / Agency code | NSF |
| Agency details / Top agency code | NSF |
| Top agency details / Code | NSF |
| Top agency details / Seed | NSF |
| Top agency details / Agency name | U.S. National Science Foundation |
| Top agency details / Agency code | NSF |
| Top agency details / Top agency code | NSF |
| Synopsis attachment folders | Not specified |
| Synopsis document urls | Not specified |
| Syn att change comments | Not specified |
| Cfdas 1 / Id | 432893 |
| Cfdas 1 / Opportunity id | 362062 |
| Cfdas 1 / Cfda number | 47.041 |
| Cfdas 1 / Program title | Engineering |
| Cfdas 2 / Id | 432897 |
| Cfdas 2 / Opportunity id | 362062 |
| Opportunity pkgs 1 / Id | 292501 |
| Opportunity pkgs 1 / Topportunity id | 362062 |
| Opportunity pkgs 1 / Family id | 14 |
| Opportunity pkgs 1 / Dialect | XFDL2.2 |
| Opportunity pkgs 1 / Opportunity number | PD-26-369Y |
| Opportunity pkgs 1 / Opportunity title | Engineering Biological and Biomedical Systems (EBBS) |
| Opportunity pkgs 1 / Opening date | 2026-04-24 |
| Opportunity pkgs 1 / Closing date | 2026-09-30 |
| Opportunity pkgs 1 / Owning agency code | NSF |
| Opportunity pkgs 1 / Agency details / Code | NSF |
| Opportunity pkgs 1 / Agency details / Seed | NSF |
| Opportunity pkgs 1 / Agency details / Agency name | U.S. National Science Foundation |
| Opportunity pkgs 1 / Agency details / Agency code | NSF |
| Opportunity pkgs 1 / Agency details / Top agency code | NSF |
| Opportunity pkgs 1 / Top agency details / Code | NSF |
| Opportunity pkgs 1 / Top agency details / Seed | NSF |
| Opportunity pkgs 1 / Top agency details / Agency name | U.S. National Science Foundation |
| Opportunity pkgs 1 / Top agency details / Agency code | NSF |
| Opportunity pkgs 1 / Top agency details / Top agency code | NSF |
| Opportunity pkgs 1 / Contact info | EBBS Program Team E-mail: cbet-ebbs@nsf.gov |
| Opportunity pkgs 1 / Grace period | 30 |
| Opportunity pkgs 1 / Electronic required | N |
| Opportunity pkgs 1 / Expected application count | 500 |
| Opportunity pkgs 1 / Open to applicant type | 3 |
| Opportunity pkgs 1 / Is multi project | N |
| Opportunity pkgs 1 / Extension | |
| Opportunity pkgs 1 / Mimetype | application/pdf |
| Opportunity pkgs 1 / Last update | Apr 27, 2026 11:25:29 PM EDT |
| Opportunity pkgs 1 / Workspace compatible flag | Y |
| Opportunity pkgs 1 / Package id | PKG00292501 |
| Opportunity pkgs 1 / Opening date str | 2026-04-24-00-00-00 |
| Opportunity pkgs 1 / Closing date str | 2026-09-30-00-00-00 |
| Closed opportunity pkgs | Not specified |
| Original due date desc | Proposals accepted anytime |
| Synopsis modified fields | revision; version; synopsisDesc; createTimeStamp |
| Forecast modified fields | Not specified |
| Error messages | Not specified |
| Syn post date in past | Yes |
| Doc type | synopsis |
| Forecast hist count | 0 |
| Synopsis hist count | 0 |
| Assist compatible | No |
| Assist url | Not specified |
| Related opps | Not specified |
| Ost | POSTED |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NSF support grantsgovsupport@nsf.gov |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| PKG00292501 | 2026-04-24 | 2026-09-30 | View |
