This grant, offered by a department focused on aging research, invites applications for Pharmacokinetic and Pharmacodynamic (PK/PD) studies targeting mTOR inhibitors. The primary purpose is to investigate the effects of mTOR inhibitors in populations living with various aging-related diseases or in relatively healthy older adults at risk for such conditions. Individual awardees will be required to collaborate as a network, facilitating information exchange, developing harmonized measures, and pooling data. This collaborative approach aims to enable a broader assessment of mTOR modulation’s impact on multiple aging outcomes and mechanisms, advancing our understanding of healthy aging and disease prevention through therapeutic intervention.
Opportunity ID: 337224
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-23-008 |
| Funding Opportunity Title: | Pharmacokinetic and Pharmacodynamic (PK/PD) Studies of mTOR Inhibitors on Aging-Related Indications (U01 Clinical Trial Required) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Jan 05, 2022 |
| Last Updated Date: | Jan 05, 2022 |
| Original Closing Date for Applications: | Jun 15, 2022 |
| Current Closing Date for Applications: | Jun 15, 2022 |
| Archive Date: | Jul 21, 2022 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Independent school districts Private institutions of higher education County governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This Funding Opportunity Announcement (FOA) invites applications for pharmacokinetic and pharmacodynamic (PK/PD) studies of mTOR inhibitors inpopulations living with different aging-related diseases or in relatively healthy older adult populations at risk for a variety of aging conditions. The studies will be funded by individual awards but will be required to interact as a network to exchange information, possibly develop harmonized measures, and pool data to facilitate broader assessment of the effects on multiple aging-related outcomes and mechanisms affected by mTOR modulation. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-23-008.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 337224 Full Announcement-RFA-AG-23-008 -> RFA-AG-23-008-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00271229 | May 14, 2022 | Jun 15, 2022 | View |
Package 1
Mandatory forms
337224 RR_SF424_5_0-5.0.pdf
337224 PHS398_CoverPageSupplement_5_0-5.0.pdf
337224 RR_OtherProjectInfo_1_4-1.4.pdf
337224 PerformanceSite_4_0-4.0.pdf
337224 RR_KeyPersonExpanded_4_0-4.0.pdf
337224 PHS398_ResearchPlan_4_0-4.0.pdf
337224 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
337224 RR_Budget_3_0-3.0.pdf
337224 RR_SubawardBudget30_3_0-3.0.pdf
337224 PHS398_ModularBudget_1_2-1.2.pdf
337224 PHS_AssignmentRequestForm_3_0-3.0.pdf
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