This grant maintains the Data Coordinating Center (DCC) for the Caenorhabditis Intervention Testing Program (CITP). The CITP rigorously tests interventions to mitigate age-related health declines in genetically diverse Caenorhabditis strains under standardized conditions, focusing on lifespan and locomotory health. The DCC coordinates consortium data, offering public access to protocols and outcomes. The next phase aims to enhance compound screening, integrate new technologies, measure transcriptomic profiles, develop aging hallmark reporters, and use them for phenotypic screens, identifying anti-aging compounds for basic and translational research.
Opportunity ID: 335834
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-AG-22-028 |
| Funding Opportunity Title: | Limited Competition:Caenorhabditis Intervention Testing Program Data Coordinating Center (U24 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.866 — Aging Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 21, 2021 |
| Last Updated Date: | Sep 21, 2021 |
| Original Closing Date for Applications: | Oct 27, 2021 |
| Current Closing Date for Applications: | Oct 27, 2021 |
| Archive Date: | Dec 02, 2021 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. See Funding Opportunity Announcement for Full Eligibility Details. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The purpose of this Funding Opportunity Announcement (FOA) is to maintain the Data Coordinating Center (DCC) for the Caenorhabditis Intervention Testing Program (CITP,) to coordinate data collection and analysis among the laboratories participating in the CITP, and to provide public access to standard operating procedures and experimental outcomes (including an accessible, annotated, and user-friendly database). The purpose of the CITP is to test, under standardized conditions at a consortium of three sites, potential intervention strategies that may moderate/alleviate health declines associated with aging across genetically diverse species and strains of Caenorhabditis. The CITP will continue to use lifespan and indicators of locomotory health as criteria for efficacious impact by targeting mechanisms likely to be conserved across phyla, but will combine compound sets derived from multiple sources, including those proposed by the biology of aging research community. The goals of next phase of the CITP are to: 1) increase the capacity to screen compounds with a high standard of rigor and reproducibility; 2) evaluate and, if warranted, implement new technologies, protocols, and genetic models of Caenorhabditis to enhance the throughput and depth of the CITP; 3) measure transcriptomic profiles to provide additional information on compounds that are effective in multiple species and/or strains, or on compounds that are effective in only a subset of species or strains; 4) develop reporters of various aging hallmarks in genetically diverse Caenorhabditis strains; and 5) use identified reporters to develop phenotypic screens against hallmarks of aging as a novel paradigm for anti-aging compounds that can have multiple uses in basic research as well as generate unique platforms for translational research. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-22-028.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
OERWebmaster03@od.nih.gov Email:OERWebmaster03@od.nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster OERWebmaster03@od.nih.gov Email: OERWebmaster03@od.nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-F | Use for due dates on or before January 24, 2022 | PKG00269069 | Sep 27, 2021 | Jan 24, 2022 | View |
Package 1
Mandatory forms
335834 RR_SF424_2_0-2.0.pdf
335834 PHS398_CoverPageSupplement_5_0-5.0.pdf
335834 RR_OtherProjectInfo_1_4-1.4.pdf
335834 PerformanceSite_2_0-2.0.pdf
335834 RR_KeyPersonExpanded_2_0-2.0.pdf
335834 RR_Budget_1_4-1.4.pdf
335834 PHS398_ResearchPlan_4_0-4.0.pdf
335834 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
335834 RR_SubawardBudget30_1_4-1.4.pdf
335834 PHS_AssignmentRequestForm_3_0-3.0.pdf
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