The BRAIN Initiative is offering this grant to scale reagent resources for precise brain cell access. This grant is for advancing viral, non-viral, transgenic, and gene regulatory element screening, integrating gene transfer, regulation, genome engineering, and atlasing methods. Applicable to human tissue and other systems, this ‘Armamentarium for Brain Cell Access’ effort aims to develop robust tools for future translational applications. Validation studies will refine resources and deepen understanding of neural gene transfer. Ultimately, this grant is for enabling precise brain cell targeting, holding immense potential for addressing human neurological disorders, such as repairing genetic mutations.
Opportunity ID: 352514
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-MH-25-100 |
| Funding Opportunity Title: | BRAIN Initiative: Scaled reagent resources for brain cell type-specific access across vertebrate species (U01 Clinical Trial Not Allowed) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Education Health Income Security and Social Services |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.173 — Research Related to Deafness and Communication Disorders |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Feb 20, 2024 |
| Last Updated Date: | Feb 20, 2024 |
| Original Closing Date for Applications: | Jan 17, 2025 |
| Current Closing Date for Applications: | Jan 17, 2025 |
| Archive Date: | Feb 22, 2025 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) County governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Special district governments Native American tribal governments (Federally recognized) |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to scale up efforts for viral, non-viral, transgenic, and gene regulatory element screening technologies and create reagent resources to access brain cell types. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Reagent development efforts will apply gene transfer, gene regulation, genome engineering, activity sensor/effector, and atlasing technologies for use in both genetically tractable and less tractable systems, including primates and human tissue, which are relevant for future translational efforts. Reagent validation studies will provide feedback to improve scaled resources, informed by deeper understanding of neural gene transfer and regulation mechanisms. Precise targeting could ultimately aid in human disorders, for example, by providing access for gene editors to specific cell types to repair mutations. |
| Link to Additional Information: | https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-100.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH Grants Information
grantsinfo@nih.gov Email:grantsinfo@nih.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 352514 Full Announcement-RFA-MH-25-100 -> RFA-MH-25-100-Full-Announcement.pdf
Packages
| Agency Contact Information: | NIH Grants Information grantsinfo@nih.gov Email: grantsinfo@nih.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or before January 24, 2025 | PKG00284951 | May 14, 2024 | Jan 24, 2025 | View |
Package 1
Mandatory forms
352514 RR_SF424_5_0-5.0.pdf
352514 PHS398_CoverPageSupplement_5_0-5.0.pdf
352514 RR_OtherProjectInfo_1_4-1.4.pdf
352514 PerformanceSite_4_0-4.0.pdf
352514 RR_KeyPersonExpanded_4_0-4.0.pdf
352514 PHS398_ResearchPlan_5_0-5.0.pdf
352514 PHSHumanSubjectsAndClinicalTrialsInfo_3_0-3.0.pdf
Optional forms
352514 RR_Budget_3_0-3.0.pdf
352514 RR_SubawardBudget30_3_0-3.0.pdf
352514 PHS398_ModularBudget_1_2-1.2.pdf
352514 PHS_AssignmentRequestForm_3_0-3.0.pdf
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