Opportunity ID: 360398
General Information
| Funding Opportunity Number | RFA-NS-27-002 |
| Funding Opportunity Title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iBCP (RM1 Clinical Trial Not Allowed) |
| Agency | National Institutes of Health |
| Document Type | synopsis |
| Version | 1 |
| Opportunity Category | Discretionary |
| Opportunity Category Explanation | Not specified |
| Funding Instrument Type | Grant |
| Category of Funding Activity | Health |
| Category Explanation | Not specified |
| Expected Number of Awards | 5 |
| Cost Sharing or Matching Requirement | No |
| Posted Date | Aug 31, 2026 12:00:00 AM EDT |
| Last Updated Date | Aug 31, 2026 12:27:02 PM EDT |
| Original Closing Date | Jun 23, 2028 12:00:00 AM EDT |
| Original Closing Date Notes | Not specified |
| Current Closing Date | Jun 23, 2028 12:00:00 AM EDT |
| Current Closing Date Notes | Not specified |
| Estimated Synopsis Date | Not specified |
| Estimated Application Due Date | Not specified |
| Estimated Award Date | Not specified |
| Estimated Project Start Date | Not specified |
| Archive Date | Aug 22, 2028 12:00:00 AM EDT |
| Estimated Total Program Funding | 1,000,000 |
| Award Ceiling | 8,000,000 |
| Award Floor | none |
Assistance Listings
- 93.173 — Research Related to Deafness and Communication Disorders
- 93.213 — Research and Training in Complementary and Integrative Health
- 93.242 — Mental Health Research Grants
- 93.273 — Alcohol Research Programs
- 93.279 — Drug Use and Addiction Research Programs
- 93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
- 93.372 — 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies
- 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
- 93.865 — Child Health and Human Development Extramural Research
- 93.866 — Aging Research
- 93.867 — Vision Research
Eligibility
| Eligible Applicants | Special district governments; Public and State controlled institutions of higher education; State governments; County governments; City or township governments; Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Native American tribal governments (Federally recognized); Others (see text field entitled "Additional Information on Eligibility" for clarification); Small businesses; Public housing authorities/Indian housing authorities |
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Description
This Notice of Funding Opportunity (NOFO) supports transdisciplinary research teams seeking to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks give rise to central nervous system (CNS) function. Teams must integrate expertise spanning molecular and cellular through systems neuroscience, with strong collaboration between experimental and computational investigators, to bridge cells, circuits, and behavior in a unified framework that yields mechanistic insight.Applications must explicitly connect three core elements: (1) characterization of circuit components (e.g., cell types and/or connectivity); (2) measurement of dynamic circuit activity, incorporating in vivo CNS recordings at cellular and sub-second temporal resolution; and (3) analyses of a tractable behavior or functional output.To address this significant challenge in neuroscience, proposed studies are expected to leverage innovative conceptual or theoretical frameworks, predictive models, and/or cutting-edge approaches that unify these three levels of analysis and bridge experimental and computational components.Recipients are expected to participate in BRAIN consortia activities to identify standards of practice towards multi-level integration.
Additional Information
| Contact | National Institutes of Health |
| Contact Information | National Institute of Neurological Disorders and Stroke (NINDS BRAINCircuits@NIH.GOV |
| BRAINCircuits@NIH.GOV | |
| Email Description | BRAINCircuits@NIH.GOV |
| Phone | 301-402-2541 |
Additional information
Version History
Version history
| Opp hist id / Opportunity id | 360398 |
| Opp hist id / Revision | 0 |
| Opportunity id | 360398 |
| Revision | 0 |
| Opportunity number | RFA-NS-26-011 |
| Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iTeamBCP (RM1 Clinical Trial Optional) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Forecast / Opp hist id / Opportunity id | 360398 |
| Forecast / Opp hist id / Revision | 0 |
| Forecast / Opportunity id | 360398 |
| Forecast / Revision | 0 |
| Forecast / Version | 1 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Karen K. David, PhD |
| Forecast / Agency contact phone | 240-328-3447 |
| Forecast / Agency contact email | BRAINCircuits@NIH.GOV |
| Forecast / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Feb 04, 2026 12:00:00 AM EST |
| Forecast / Est application response date | Jun 16, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Est project start date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Fiscal year | 2027 |
| Forecast / Create time stamp | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 09:20:22 AM EDT |
| Forecast / Created date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Last updated date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 25 |
| Forecast / Applicant types 1 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 2 / Id | 11 |
| Forecast / Applicant types 2 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 3 / Id | 06 |
| Forecast / Applicant types 3 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 4 / Id | 08 |
| Forecast / Applicant types 4 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 5 / Id | 12 |
| Forecast / Applicant types 5 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 6 / Id | 20 |
| Forecast / Applicant types 6 / Description | Private institutions of higher education |
| Forecast / Applicant types 7 / Id | 04 |
| Forecast / Applicant types 7 / Description | Special district governments |
| Forecast / Applicant types 8 / Id | 22 |
| Forecast / Applicant types 8 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 9 / Id | 01 |
| Forecast / Applicant types 9 / Description | County governments |
| Forecast / Applicant types 10 / Id | 00 |
| Forecast / Applicant types 10 / Description | State governments |
| Forecast / Applicant types 11 / Id | 23 |
| Forecast / Applicant types 11 / Description | Small businesses |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 13 |
| Forecast / Applicant types 13 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 14 / Id | 02 |
| Forecast / Applicant types 14 / Description | City or township governments |
| Forecast / Applicant types 15 / Id | 05 |
| Forecast / Applicant types 15 / Description | Independent school districts |
| Forecast / Funding instruments 1 / Id | G |
| Forecast / Funding instruments 1 / Description | Grant |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2026-02-04-00-00-00 |
| Forecast / Est application response date str | 2026-06-16-00-00-00 |
| Forecast / Est award date str | 2027-04-01-00-00-00 |
| Forecast / Est project start date str | 2027-04-01-00-00-00 |
| Forecast / Create time stamp str | 2025-08-28-15-27-29 |
| Cfdas 1 / Id | 430753 |
| Cfdas 1 / Opportunity id | 360398 |
| Cfdas 1 / Revision | 3 |
| Cfdas 1 / Cfda number | 93.372 |
| Cfdas 1 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Cfdas 2 / Id | 430752 |
| Cfdas 2 / Opportunity id | 360398 |
| Cfdas 2 / Revision | 3 |
| Cfdas 2 / Cfda number | 93.853 |
| Cfdas 2 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Synopsis modified fields | Not specified |
| Forecast modified fields | Not specified |
| Opp hist id / Opportunity id | 360398 |
| Opp hist id / Revision | 1 |
| Opportunity id | 360398 |
| Revision | 1 |
| Opportunity number | RFA-NS-27-002 |
| Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iTeamBCP (RM1 Clinical Trial Optional) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Modified comments | Updated details to match current NOFO. |
| Forecast / Opp hist id / Opportunity id | 360398 |
| Forecast / Opp hist id / Revision | 1 |
| Forecast / Opportunity id | 360398 |
| Forecast / Revision | 1 |
| Forecast / Version | 2 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Karen K. David, PhD |
| Forecast / Agency contact phone | 240-328-3447 |
| Forecast / Agency contact email | BRAINCircuits@NIH.GOV |
| Forecast / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Feb 04, 2026 12:00:00 AM EST |
| Forecast / Est application response date | Jun 16, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Est project start date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Updated details to match current NOFO. |
| Forecast / Create time stamp | Aug 31, 2026 09:20:22 AM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 12:18:25 PM EDT |
| Forecast / Created date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 09:20:22 AM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 25 |
| Forecast / Applicant types 1 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 2 / Id | 11 |
| Forecast / Applicant types 2 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 3 / Id | 06 |
| Forecast / Applicant types 3 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 4 / Id | 08 |
| Forecast / Applicant types 4 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 5 / Id | 12 |
| Forecast / Applicant types 5 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 6 / Id | 20 |
| Forecast / Applicant types 6 / Description | Private institutions of higher education |
| Forecast / Applicant types 7 / Id | 04 |
| Forecast / Applicant types 7 / Description | Special district governments |
| Forecast / Applicant types 8 / Id | 22 |
| Forecast / Applicant types 8 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 9 / Id | 01 |
| Forecast / Applicant types 9 / Description | County governments |
| Forecast / Applicant types 10 / Id | 00 |
| Forecast / Applicant types 10 / Description | State governments |
| Forecast / Applicant types 11 / Id | 23 |
| Forecast / Applicant types 11 / Description | Small businesses |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 13 |
| Forecast / Applicant types 13 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 14 / Id | 02 |
| Forecast / Applicant types 14 / Description | City or township governments |
| Forecast / Applicant types 15 / Id | 05 |
| Forecast / Applicant types 15 / Description | Independent school districts |
| Forecast / Funding instruments 1 / Id | G |
| Forecast / Funding instruments 1 / Description | Grant |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2026-02-04-00-00-00 |
| Forecast / Est application response date str | 2026-06-16-00-00-00 |
| Forecast / Est award date str | 2027-04-01-00-00-00 |
| Forecast / Est project start date str | 2027-04-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-09-20-22 |
| Cfdas 1 / Id | 430753 |
| Cfdas 1 / Opportunity id | 360398 |
| Cfdas 1 / Revision | 3 |
| Cfdas 1 / Cfda number | 93.372 |
| Cfdas 1 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Cfdas 2 / Id | 430752 |
| Cfdas 2 / Opportunity id | 360398 |
| Cfdas 2 / Revision | 3 |
| Cfdas 2 / Cfda number | 93.853 |
| Cfdas 2 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; opportunityNumber; sendEmail; modComments; createTimeStamp |
| Opp hist id / Opportunity id | 360398 |
| Opp hist id / Revision | 2 |
| Opportunity id | 360398 |
| Revision | 2 |
| Opportunity number | RFA-NS-27-002 |
| Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iBCP (RM1 Clinical Trial Not Allowed) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Modified comments | Details update to match current NOFO. |
| Forecast / Opp hist id / Opportunity id | 360398 |
| Forecast / Opp hist id / Revision | 2 |
| Forecast / Opportunity id | 360398 |
| Forecast / Revision | 2 |
| Forecast / Version | 3 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Karen K. David, PhD |
| Forecast / Agency contact phone | 240-328-3447 |
| Forecast / Agency contact email | BRAINCircuits@NIH.GOV |
| Forecast / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Feb 04, 2026 12:00:00 AM EST |
| Forecast / Est application response date | Jun 16, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Est project start date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Details update to match current NOFO. |
| Forecast / Create time stamp | Aug 31, 2026 12:18:25 PM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 12:27:01 PM EDT |
| Forecast / Created date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 12:18:25 PM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 25 |
| Forecast / Applicant types 1 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 2 / Id | 11 |
| Forecast / Applicant types 2 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 3 / Id | 06 |
| Forecast / Applicant types 3 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 4 / Id | 08 |
| Forecast / Applicant types 4 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 5 / Id | 12 |
| Forecast / Applicant types 5 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 6 / Id | 20 |
| Forecast / Applicant types 6 / Description | Private institutions of higher education |
| Forecast / Applicant types 7 / Id | 04 |
| Forecast / Applicant types 7 / Description | Special district governments |
| Forecast / Applicant types 8 / Id | 22 |
| Forecast / Applicant types 8 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 9 / Id | 01 |
| Forecast / Applicant types 9 / Description | County governments |
| Forecast / Applicant types 10 / Id | 00 |
| Forecast / Applicant types 10 / Description | State governments |
| Forecast / Applicant types 11 / Id | 23 |
| Forecast / Applicant types 11 / Description | Small businesses |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 13 |
| Forecast / Applicant types 13 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 14 / Id | 02 |
| Forecast / Applicant types 14 / Description | City or township governments |
| Forecast / Applicant types 15 / Id | 05 |
| Forecast / Applicant types 15 / Description | Independent school districts |
| Forecast / Funding instruments 1 / Id | G |
| Forecast / Funding instruments 1 / Description | Grant |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2026-02-04-00-00-00 |
| Forecast / Est application response date str | 2026-06-16-00-00-00 |
| Forecast / Est award date str | 2027-04-01-00-00-00 |
| Forecast / Est project start date str | 2027-04-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-12-18-25 |
| Cfdas 1 / Id | 430753 |
| Cfdas 1 / Opportunity id | 360398 |
| Cfdas 1 / Revision | 3 |
| Cfdas 1 / Cfda number | 93.372 |
| Cfdas 1 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Cfdas 2 / Id | 430752 |
| Cfdas 2 / Opportunity id | 360398 |
| Cfdas 2 / Revision | 3 |
| Cfdas 2 / Cfda number | 93.853 |
| Cfdas 2 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; opportunityTitle; modComments |
| Opp hist id / Opportunity id | 360398 |
| Opp hist id / Revision | 4 |
| Opportunity id | 360398 |
| Revision | 4 |
| Opportunity number | RFA-NS-27-002 |
| Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iBCP (RM1 Clinical Trial Not Allowed) |
| Owning agency code | HHS-NIH11 |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Modified comments | Details update to match current NOFO. |
| Forecast / Opp hist id / Opportunity id | 360398 |
| Forecast / Opp hist id / Revision | 4 |
| Forecast / Opportunity id | 360398 |
| Forecast / Revision | 4 |
| Forecast / Version | 4 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Karen K. David, PhD |
| Forecast / Agency contact phone | 240-328-3447 |
| Forecast / Agency contact email | BRAINCircuits@NIH.GOV |
| Forecast / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Feb 04, 2026 12:00:00 AM EST |
| Forecast / Est application response date | Jun 16, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Est project start date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Details update to match current NOFO. |
| Forecast / Create time stamp | Aug 31, 2026 12:27:01 PM EDT |
| Forecast / Action type | U |
| Forecast / Action date | Aug 31, 2026 12:27:02 PM EDT |
| Forecast / Created date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 12:27:01 PM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 25 |
| Forecast / Applicant types 1 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 2 / Id | 11 |
| Forecast / Applicant types 2 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 3 / Id | 06 |
| Forecast / Applicant types 3 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 4 / Id | 08 |
| Forecast / Applicant types 4 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Applicant types 5 / Id | 12 |
| Forecast / Applicant types 5 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 6 / Id | 20 |
| Forecast / Applicant types 6 / Description | Private institutions of higher education |
| Forecast / Applicant types 7 / Id | 04 |
| Forecast / Applicant types 7 / Description | Special district governments |
| Forecast / Applicant types 8 / Id | 22 |
| Forecast / Applicant types 8 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 9 / Id | 01 |
| Forecast / Applicant types 9 / Description | County governments |
| Forecast / Applicant types 10 / Id | 00 |
| Forecast / Applicant types 10 / Description | State governments |
| Forecast / Applicant types 11 / Id | 23 |
| Forecast / Applicant types 11 / Description | Small businesses |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 13 |
| Forecast / Applicant types 13 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 14 / Id | 02 |
| Forecast / Applicant types 14 / Description | City or township governments |
| Forecast / Applicant types 15 / Id | 05 |
| Forecast / Applicant types 15 / Description | Independent school districts |
| Forecast / Funding instruments 1 / Id | G |
| Forecast / Funding instruments 1 / Description | Grant |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Est synopsis posting date str | 2026-02-04-00-00-00 |
| Forecast / Est application response date str | 2026-06-16-00-00-00 |
| Forecast / Est award date str | 2027-04-01-00-00-00 |
| Forecast / Est project start date str | 2027-04-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-12-27-01 |
| Cfdas 1 / Id | 435256 |
| Cfdas 1 / Opportunity id | 360398 |
| Cfdas 1 / Revision | 3 |
| Cfdas 1 / Cfda number | 93.173 |
| Cfdas 1 / Program title | Research Related to Deafness and Communication Disorders |
| Cfdas 2 / Id | 435262 |
| Cfdas 2 / Opportunity id | 360398 |
| Cfdas 2 / Revision | 3 |
| Cfdas 2 / Cfda number | 93.213 |
| Cfdas 2 / Program title | Research and Training in Complementary and Integrative Health |
| Cfdas 3 / Id | 435258 |
| Cfdas 3 / Opportunity id | 360398 |
| Cfdas 3 / Revision | 3 |
| Cfdas 3 / Cfda number | 93.242 |
| Cfdas 3 / Program title | Mental Health Research Grants |
| Cfdas 4 / Id | 435260 |
| Cfdas 4 / Opportunity id | 360398 |
| Cfdas 4 / Revision | 3 |
| Cfdas 4 / Cfda number | 93.273 |
| Cfdas 4 / Program title | Alcohol Research Programs |
| Cfdas 5 / Id | 435261 |
| Cfdas 5 / Opportunity id | 360398 |
| Cfdas 5 / Revision | 3 |
| Cfdas 5 / Cfda number | 93.279 |
| Cfdas 5 / Program title | Drug Use and Addiction Research Programs |
| Cfdas 6 / Id | 435259 |
| Cfdas 6 / Opportunity id | 360398 |
| Cfdas 6 / Revision | 3 |
| Cfdas 6 / Cfda number | 93.286 |
| Cfdas 6 / Program title | Discovery and Applied Research for Technological Innovations to Improve Human Health |
| Cfdas 7 / Id | 430753 |
| Cfdas 7 / Opportunity id | 360398 |
| Cfdas 7 / Revision | 3 |
| Cfdas 7 / Cfda number | 93.372 |
| Cfdas 7 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Cfdas 8 / Id | 430752 |
| Cfdas 8 / Opportunity id | 360398 |
| Cfdas 8 / Revision | 3 |
| Cfdas 8 / Cfda number | 93.853 |
| Cfdas 8 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cfdas 9 / Id | 435257 |
| Cfdas 9 / Opportunity id | 360398 |
| Cfdas 9 / Revision | 3 |
| Cfdas 9 / Cfda number | 93.865 |
| Cfdas 9 / Program title | Child Health and Human Development Extramural Research |
| Cfdas 10 / Id | 435263 |
| Cfdas 10 / Opportunity id | 360398 |
| Cfdas 10 / Revision | 3 |
| Cfdas 10 / Cfda number | 93.866 |
| Cfdas 10 / Program title | Aging Research |
| Cfdas 11 / Id | 435255 |
| Cfdas 11 / Opportunity id | 360398 |
| Cfdas 11 / Revision | 3 |
| Cfdas 11 / Cfda number | 93.867 |
| Cfdas 11 / Program title | Vision Research |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; cfdas; sendEmail |
Forecast changes
revision
version
archiveDate
modComments
| Id | 360398 |
| Revision | 5 |
| Opportunity number | RFA-NS-27-002 |
| Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iBCP (RM1 Clinical Trial Not Allowed) |
| Owning agency code | HHS-NIH11 |
| Modified comments | Details update to match current NOFO. |
| Opportunity category / Category | D |
| Opportunity category / Description | Discretionary |
| Synopsis / Opportunity id | 360398 |
| Synopsis / Version | 1 |
| Synopsis / Agency code | HHS-NIH11 |
| Synopsis / Agency name | National Institutes of Health |
| Synopsis / Agency phone | 301-402-2541 |
| Synopsis / Agency address desc | BRAINCircuits@NIH.GOV |
| Synopsis / Agency details / Code | NIH |
| Synopsis / Agency details / Seed | HHS-NIH11 |
| Synopsis / Agency details / Agency name | National Institutes of Health |
| Synopsis / Agency details / Agency code | HHS-NIH11 |
| Synopsis / Agency details / Top agency code | HHS |
| Synopsis / Top agency details / Code | HHS |
| Synopsis / Top agency details / Seed | HHS |
| Synopsis / Top agency details / Agency name | Department of Health and Human Services |
| Synopsis / Top agency details / Agency code | HHS |
| Synopsis / Top agency details / Top agency code | HHS |
| Synopsis / Agency contact phone | 301-402-2541 |
| Synopsis / Agency contact name | National Institutes of Health |
| Synopsis / Agency contact desc | National Institute of Neurological Disorders and Stroke (NINDS BRAINCircuits@NIH.GOV |
| Synopsis / Agency contact email | BRAINCircuits@NIH.GOV |
| Synopsis / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Synopsis / Synopsis desc | This Notice of Funding Opportunity (NOFO) supports transdisciplinary research teams seeking to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks give rise to central nervous system (CNS) function. Teams must integrate expertise spanning molecular and cellular through systems neuroscience, with strong collaboration between experimental and computational investigators, to bridge cells, circuits, and behavior in a unified framework that yields mechanistic insight.Applications must explicitly connect three core elements: (1) characterization of circuit components (e.g., cell types and/or connectivity); (2) measurement of dynamic circuit activity, incorporating in vivo CNS recordings at cellular and sub-second temporal resolution; and (3) analyses of a tractable behavior or functional output.To address this significant challenge in neuroscience, proposed studies are expected to leverage innovative conceptual or theoretical frameworks, predictive models, and/or cutting-edge approaches that unify these three levels of analysis and bridge experimental and computational components.Recipients are expected to participate in BRAIN consortia activities to identify standards of practice towards multi-level integration. |
| Synopsis / Response date | Jun 23, 2028 12:00:00 AM EDT |
| Synopsis / Posting date | Aug 31, 2026 12:00:00 AM EDT |
| Synopsis / Archive date | Aug 22, 2028 12:00:00 AM EDT |
| Synopsis / Cost sharing | No |
| Synopsis / Number of awards | 5 |
| Synopsis / Estimated funding | 1000000 |
| Synopsis / Estimated funding formatted | 1,000,000 |
| Synopsis / Award ceiling | 8000000 |
| Synopsis / Award ceiling formatted | 8,000,000 |
| Synopsis / Award floor | none |
| Synopsis / Applicant eligibility desc | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors. |
| Synopsis / Create time stamp | Aug 31, 2026 12:27:24 PM EDT |
| Synopsis / Created date | Aug 31, 2026 12:27:02 PM EDT |
| Synopsis / Last updated date | Aug 31, 2026 12:27:02 PM EDT |
| Synopsis / Applicant types 1 / Id | 04 |
| Synopsis / Applicant types 1 / Description | Special district governments |
| Synopsis / Applicant types 2 / Id | 06 |
| Synopsis / Applicant types 2 / Description | Public and State controlled institutions of higher education |
| Synopsis / Applicant types 3 / Id | 00 |
| Synopsis / Applicant types 3 / Description | State governments |
| Synopsis / Applicant types 4 / Id | 01 |
| Synopsis / Applicant types 4 / Description | County governments |
| Synopsis / Applicant types 5 / Id | 02 |
| Synopsis / Applicant types 5 / Description | City or township governments |
| Synopsis / Applicant types 6 / Id | 20 |
| Synopsis / Applicant types 6 / Description | Private institutions of higher education |
| Synopsis / Applicant types 7 / Id | 12 |
| Synopsis / Applicant types 7 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Applicant types 8 / Id | 05 |
| Synopsis / Applicant types 8 / Description | Independent school districts |
| Synopsis / Applicant types 9 / Id | 22 |
| Synopsis / Applicant types 9 / Description | For profit organizations other than small businesses |
| Synopsis / Applicant types 10 / Id | 13 |
| Synopsis / Applicant types 10 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Synopsis / Applicant types 11 / Id | 11 |
| Synopsis / Applicant types 11 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Synopsis / Applicant types 12 / Id | 07 |
| Synopsis / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Synopsis / Applicant types 13 / Id | 25 |
| Synopsis / Applicant types 13 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Synopsis / Applicant types 14 / Id | 23 |
| Synopsis / Applicant types 14 / Description | Small businesses |
| Synopsis / Applicant types 15 / Id | 08 |
| Synopsis / Applicant types 15 / Description | Public housing authorities/Indian housing authorities |
| Synopsis / Funding instruments 1 / Id | G |
| Synopsis / Funding instruments 1 / Description | Grant |
| Synopsis / Funding activity categories 1 / Id | HL |
| Synopsis / Funding activity categories 1 / Description | Health |
| Synopsis / Response date str | 2028-06-23-00-00-00 |
| Synopsis / Posting date str | 2026-08-31-00-00-00 |
| Synopsis / Archive date str | 2028-08-22-00-00-00 |
| Synopsis / Create time stamp str | 2026-08-31-12-27-24 |
| Agency details / Code | NIH |
| Agency details / Seed | HHS-NIH11 |
| Agency details / Agency name | National Institutes of Health |
| Agency details / Agency code | HHS-NIH11 |
| Agency details / Top agency code | HHS |
| Top agency details / Code | HHS |
| Top agency details / Seed | HHS |
| Top agency details / Agency name | Department of Health and Human Services |
| Top agency details / Agency code | HHS |
| Top agency details / Top agency code | HHS |
| Forecast / Opportunity id | 360398 |
| Forecast / Version | 5 |
| Forecast / Posting date | Aug 28, 2025 12:00:00 AM EDT |
| Forecast / Archive date | Aug 30, 2026 12:00:00 AM EDT |
| Forecast / Forecast desc | The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), the National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Drug Abuse (NIDA) National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), and Office of Behavioral and Social Sciences Research (OBSSR), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from teams to understand how the nervous system, from its individual components to its unified whole, gives rise to mental experience and behavior. Teams must integrate distinct expertise of 3-6 PDs/PIs to deliver fundamental principles about central nervous system (CNS) function through theories, models, and approaches that bridge cells, circuits, behavior. Applications must connect these 3 levels of analysis: (1) rich large-scale information about circuit components (e.g., cell types, connectivity), (2) in vivo CNS recordings at cellular and sub-second and temporal resolution, (3) along with analyses of a tractable behavior of an organism or a well-defined neural system. Projects may also include the development of tools and approaches to surmount key research roadblocks. Experimental systems should be chosen for their potential to optimize integrative approaches and reveal generalizable, multi-scale principles about CNS computations underlying function and behavior. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of integrative systems neuroscience are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in molecular, cellular, systems, behavioral, computational, and theoretical neuroscience, as well as in engineering, data science, mathematics, physics, and statistics, as appropriate, will be encouraged and these investigators should also begin considering applying for this application. |
| Forecast / Cost sharing | No |
| Forecast / Agency contact name | Karen K. David, PhD |
| Forecast / Agency contact phone | 240-328-3447 |
| Forecast / Agency contact email | BRAINCircuits@NIH.GOV |
| Forecast / Agency contact email desc | BRAINCircuits@NIH.GOV |
| Forecast / Agency code | HHS-NIH11 |
| Forecast / Applicant eligibility desc | Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). |
| Forecast / Est synopsis posting date | Feb 04, 2026 12:00:00 AM EST |
| Forecast / Est application response date | Jun 16, 2026 12:00:00 AM EDT |
| Forecast / Est award date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Est project start date | Apr 01, 2027 12:00:00 AM EDT |
| Forecast / Fiscal year | 2027 |
| Forecast / Mod comments | Updated Archive Date |
| Forecast / Create time stamp | Aug 31, 2026 12:27:24 PM EDT |
| Forecast / Created date | Aug 28, 2025 03:27:29 PM EDT |
| Forecast / Last updated date | Aug 31, 2026 12:27:24 PM EDT |
| Forecast / Agency details / Code | NIH |
| Forecast / Agency details / Seed | HHS-NIH11 |
| Forecast / Agency details / Agency name | National Institutes of Health |
| Forecast / Agency details / Agency code | HHS-NIH11 |
| Forecast / Agency details / Top agency code | HHS |
| Forecast / Applicant types 1 / Id | 04 |
| Forecast / Applicant types 1 / Description | Special district governments |
| Forecast / Applicant types 2 / Id | 06 |
| Forecast / Applicant types 2 / Description | Public and State controlled institutions of higher education |
| Forecast / Applicant types 3 / Id | 00 |
| Forecast / Applicant types 3 / Description | State governments |
| Forecast / Applicant types 4 / Id | 01 |
| Forecast / Applicant types 4 / Description | County governments |
| Forecast / Applicant types 5 / Id | 02 |
| Forecast / Applicant types 5 / Description | City or township governments |
| Forecast / Applicant types 6 / Id | 20 |
| Forecast / Applicant types 6 / Description | Private institutions of higher education |
| Forecast / Applicant types 7 / Id | 12 |
| Forecast / Applicant types 7 / Description | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 8 / Id | 05 |
| Forecast / Applicant types 8 / Description | Independent school districts |
| Forecast / Applicant types 9 / Id | 22 |
| Forecast / Applicant types 9 / Description | For profit organizations other than small businesses |
| Forecast / Applicant types 10 / Id | 13 |
| Forecast / Applicant types 10 / Description | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Forecast / Applicant types 11 / Id | 11 |
| Forecast / Applicant types 11 / Description | Native American tribal organizations (other than Federally recognized tribal governments) |
| Forecast / Applicant types 12 / Id | 07 |
| Forecast / Applicant types 12 / Description | Native American tribal governments (Federally recognized) |
| Forecast / Applicant types 13 / Id | 25 |
| Forecast / Applicant types 13 / Description | Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Forecast / Applicant types 14 / Id | 23 |
| Forecast / Applicant types 14 / Description | Small businesses |
| Forecast / Applicant types 15 / Id | 08 |
| Forecast / Applicant types 15 / Description | Public housing authorities/Indian housing authorities |
| Forecast / Funding instruments 1 / Id | G |
| Forecast / Funding instruments 1 / Description | Grant |
| Forecast / Funding activity categories 1 / Id | HL |
| Forecast / Funding activity categories 1 / Description | Health |
| Forecast / Posting date str | 2025-08-28-00-00-00 |
| Forecast / Archive date str | 2026-08-30-00-00-00 |
| Forecast / Est synopsis posting date str | 2026-02-04-00-00-00 |
| Forecast / Est application response date str | 2026-06-16-00-00-00 |
| Forecast / Est award date str | 2027-04-01-00-00-00 |
| Forecast / Est project start date str | 2027-04-01-00-00-00 |
| Forecast / Create time stamp str | 2026-08-31-12-27-24 |
| Synopsis attachment folders 1 / Id | 81216 |
| Synopsis attachment folders 1 / Opportunity id | 360398 |
| Synopsis attachment folders 1 / Folder type | Full Announcement |
| Synopsis attachment folders 1 / Folder name | Full Announcement |
| Synopsis attachment folders 1 / Zip lob size | 36466 |
| Synopsis attachment folders 1 / Created date | Aug 31, 2026 12:27:24 PM EDT |
| Synopsis attachment folders 1 / Last updated date | Aug 31, 2026 12:27:24 PM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Id | 354882 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Opportunity id | 360398 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Mime type | text/html;charset=UTF-8 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File name | RFA-NS-27-002-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File description | RFA-NS-27-002-Full-Announcement.html |
| Synopsis attachment folders 1 / Synopsis attachments 1 / File lob size | 152514 |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Created date | Aug 31, 2026 12:27:24 PM EDT |
| Synopsis attachment folders 1 / Synopsis attachments 1 / Synopsis att folder id | 81216 |
| Synopsis document urls | Not specified |
| Syn att change comments | Not specified |
| Cfdas 1 / Id | 435256 |
| Cfdas 1 / Opportunity id | 360398 |
| Cfdas 1 / Cfda number | 93.173 |
| Cfdas 1 / Program title | Research Related to Deafness and Communication Disorders |
| Cfdas 2 / Id | 435262 |
| Cfdas 2 / Opportunity id | 360398 |
| Cfdas 2 / Cfda number | 93.213 |
| Cfdas 2 / Program title | Research and Training in Complementary and Integrative Health |
| Cfdas 3 / Id | 435258 |
| Cfdas 3 / Opportunity id | 360398 |
| Cfdas 3 / Cfda number | 93.242 |
| Cfdas 3 / Program title | Mental Health Research Grants |
| Cfdas 4 / Id | 435260 |
| Cfdas 4 / Opportunity id | 360398 |
| Cfdas 4 / Cfda number | 93.273 |
| Cfdas 4 / Program title | Alcohol Research Programs |
| Cfdas 5 / Id | 435261 |
| Cfdas 5 / Opportunity id | 360398 |
| Cfdas 5 / Cfda number | 93.279 |
| Cfdas 5 / Program title | Drug Use and Addiction Research Programs |
| Cfdas 6 / Id | 435259 |
| Cfdas 6 / Opportunity id | 360398 |
| Cfdas 6 / Cfda number | 93.286 |
| Cfdas 6 / Program title | Discovery and Applied Research for Technological Innovations to Improve Human Health |
| Cfdas 7 / Id | 430753 |
| Cfdas 7 / Opportunity id | 360398 |
| Cfdas 7 / Cfda number | 93.372 |
| Cfdas 7 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Cfdas 8 / Id | 430752 |
| Cfdas 8 / Opportunity id | 360398 |
| Cfdas 8 / Cfda number | 93.853 |
| Cfdas 8 / Program title | Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cfdas 9 / Id | 435257 |
| Cfdas 9 / Opportunity id | 360398 |
| Cfdas 9 / Cfda number | 93.865 |
| Cfdas 9 / Program title | Child Health and Human Development Extramural Research |
| Cfdas 10 / Id | 435263 |
| Cfdas 10 / Opportunity id | 360398 |
| Cfdas 10 / Cfda number | 93.866 |
| Cfdas 10 / Program title | Aging Research |
| Cfdas 11 / Id | 435255 |
| Cfdas 11 / Opportunity id | 360398 |
| Cfdas 11 / Cfda number | 93.867 |
| Cfdas 11 / Program title | Vision Research |
| Opportunity pkgs 1 / Id | 294092 |
| Opportunity pkgs 1 / Topportunity id | 360398 |
| Opportunity pkgs 1 / Family id | 14 |
| Opportunity pkgs 1 / Dialect | XFDL2.2 |
| Opportunity pkgs 1 / Opportunity number | RFA-NS-27-002 |
| Opportunity pkgs 1 / Opportunity title | BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program – iBCP (RM1 Clinical Trial Not Allowed) |
| Opportunity pkgs 1 / Cfda number | 93.372 |
| Opportunity pkgs 1 / Opening date | 2026-09-07 |
| Opportunity pkgs 1 / Closing date | 2028-06-23 |
| Opportunity pkgs 1 / Owning agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Code | NIH |
| Opportunity pkgs 1 / Agency details / Seed | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Agency name | National Institutes of Health |
| Opportunity pkgs 1 / Agency details / Agency code | HHS-NIH11 |
| Opportunity pkgs 1 / Agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Code | HHS |
| Opportunity pkgs 1 / Top agency details / Seed | HHS |
| Opportunity pkgs 1 / Top agency details / Agency name | Department of Health and Human Services |
| Opportunity pkgs 1 / Top agency details / Agency code | HHS |
| Opportunity pkgs 1 / Top agency details / Top agency code | HHS |
| Opportunity pkgs 1 / Program title | 21st Century Cures Act – Brain Research through Advancing Innovative Neurotechnologies |
| Opportunity pkgs 1 / Contact info | eRA Service Desk https://www.era.nih.gov/need-help |
| Opportunity pkgs 1 / Grace period | 35 |
| Opportunity pkgs 1 / Competition id | FORMS-I |
| Opportunity pkgs 1 / Competition title | Use for due date on or after January 25, 2025. |
| Opportunity pkgs 1 / Electronic required | Y |
| Opportunity pkgs 1 / Expected application count | 100 |
| Opportunity pkgs 1 / Open to applicant type | 1 |
| Opportunity pkgs 1 / Is multi project | N |
| Opportunity pkgs 1 / Extension | |
| Opportunity pkgs 1 / Mimetype | application/pdf |
| Opportunity pkgs 1 / Last update | Aug 31, 2026 12:30:03 PM EDT |
| Opportunity pkgs 1 / Workspace compatible flag | Y |
| Opportunity pkgs 1 / Package id | PKG00294092 |
| Opportunity pkgs 1 / Opening date str | 2026-09-07-00-00-00 |
| Opportunity pkgs 1 / Closing date str | 2028-06-23-00-00-00 |
| Closed opportunity pkgs | Not specified |
| Original due date | Jun 23, 2028 12:00:00 AM EDT |
| Synopsis modified fields | Not specified |
| Forecast modified fields | revision; version; archiveDate; modComments |
| Error messages | Not specified |
| Syn post date in past | Yes |
| Doc type | synopsis |
| Forecast hist count | 4 |
| Synopsis hist count | 0 |
| Assist compatible | No |
| Assist url | Not specified |
| Related opps | Not specified |
| Ost | POSTED |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | National Institute of Neurological Disorders and Stroke (NINDS BRAINCircuits@NIH.GOV |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.372 | FORMS-I | Use for due date on or after January 25, 2025. | PKG00294092 | 2026-09-07 | 2028-06-23 | View |
Package 1
Instructions
PKG00294120-instructions.pdf
Mandatory forms
RR_SF424_5_0-V5.0.pdf
PHS398_CoverPageSupplement_5_0-V5.0.pdf
RR_OtherProjectInfo_1_4-V1.4.pdf
PerformanceSite_4_0-V4.0.pdf
RR_KeyPersonExpanded_4_0-V4.0.pdf
RR_Budget10_3_0-V3.0.pdf
PHS398_ResearchPlan_5_0-V5.0.pdf
PHSHumanSubjectsAndClinicalTrialsInfo_3_0-V3.0.pdf
Optional forms
RR_SubawardBudget10_30_3_0-V3.0.pdf
PHS_AssignmentRequestForm_4_0-V4.0.pdf
