This CDC grant supports the Global Polio Eradication Initiative (GPEI), aiming for worldwide poliovirus eradication. Significant progress includes WPV types 2 and 3 eradication, and five WHO regions certified WPV-free. Remaining challenges involve persistent WPV1 circulation in Afghanistan and Pakistan, plus increasing vaccine-derived poliovirus (cVDPV) outbreaks. This grant is for expanding integrated modeling work, leveraging nearly two decades of collaboration between Kid Risk and CDC. The awardee will conduct advanced modeling to characterize poliovirus transmission, evaluate policy options, and inform strategies for addressing cVDPV2 outbreaks, novel vaccine use, and achieving WPV eradication in endemic areas. The initiative also covers other vaccine-preventable diseases.
Opportunity ID: 330329
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | CDC-RFA-GH21-2101 |
| Funding Opportunity Title: | Support of Global Polio Eradication Initiative (GPEI) using Integrated Modeling |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 1 |
| Assistance Listings: | 93.185 — Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 11, 2020 |
| Last Updated Date: | Dec 11, 2020 |
| Original Closing Date for Applications: | Feb 11, 2021 Electronically submitted applications must be submitted no later than 11:59 p.m., ET, on the listed application due date. |
| Current Closing Date for Applications: | Feb 11, 2021 Electronically submitted applications must be submitted no later than 11:59 p.m., ET, on the listed application due date. |
| Archive Date: | Mar 13, 2021 |
| Estimated Total Program Funding: | $3,750,000 |
| Award Ceiling: | $0 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Single Eligibility – KidRisk Inc. Eligibility is limited to: KidRisk Inc. 7512 Dr. Phillip Blvd. Ste. 50-523 Orlando, Florida 32819 |
Additional Information
| Agency Name: | Centers for Disease Control – CGH |
| Description: | The Global Polio Eradication Initiative (GPEI) began in 1988 with the objective of wild poliovirus (WPV) eradication and ultimate full poliovirus eradication. CDC was one of the founding partners of the GPEI, and polio eradication remains an agency-wide priority; CDC’s Emergency Operations Center has been activated since December 2011 for global polio response activities. CDC is currently one of six partners in GPEI, providing technical and financial support for polio eradication and childhood immunization activities along with the World Health Organization (WHO), Rotary International, United Nations Children’s Fund (UNICEF), the Bill and Melinda Gates Foundation (BMGF), and Gavi, the Vaccine Alliance. The GPEI has made tremendous progress toward global eradication with WPV circulating in only 2 countries in 2020, Afghanistan and Pakistan, down from 125 countries in 1988. WPV type 2 and 3 have been successfully certified as eradicated with only type 1 WPV remaining. With the certification of WHO’s African Region as free of WPV on August 25, 2020, five of WHO’s six Regions are now declared WPV free. Only the Eastern Mediterranean Region has yet to achieve this goal. The GPEI now faces two major challenges: 1) continued transmission of WPV1 in Pakistan and Afghanistan and 2) an increasing number of outbreaks of circulating Vaccine Derived Polioviruses (cVDPVs) which result from prolonged circulation in under-immunized communities of the live weakened virus from the oral poliovirus vaccine (OPV). Kid Risk and CDC have collaboratively addressed complex polio eradication issues for almost 20 years to inform policymaking by CDC and GPEI. The work completed under the most recent cooperative agreement (NU2RGH001913) included updates to the global integrated economic, risk and dynamic disease model to reflect the current GPEI strategic planning and implementation efforts to characterize poliovirus transmission and assess the health and economic trade-offs associated with different policy options. Kid Risk’s expanded and updated poliovirus transmission model accounts for differences in serotype and transmission routes, routine childhood immunization schedules, Sabin OPV evolution in transmission and the emergence of cVDPVs, particularly type 2 (cVDPV2). During 2019, Kid Risk focused on characterizing WPV transmission in Borno and Yobe states of northeast Nigeria and the confidence in the available evidence of no transmission of WPV, to inform the Africa Region Certification Commission’s evaluation of certifying the region WPV-free. In addition, in 2020, they have modeled the changing cVDPV2 epidemiology and risk of different response strategies that may result in restarting Sabin type 2 in routine immunization schedules, and what potential outcomes are possible with wide scale use of a novel, stabilized type 2 OPV. Numerous key questions about the polio eradication endgame remain, particularly the best vaccine strategies to address cVDPV2 outbreaks and ultimately withdraw all use of Sabin OPV. At this stage of the GPEI, modeling of new strategies is required, particularly with respect to use of a stabilized, novel OPV type 2 and other outbreak strategies to stop and prevent VDPV2 outbreaks, as well as how to achieve WPV eradication in Pakistan and Afghanistan. This announcement requests the awardee to expand upon their work as part of CDC’s GPEI support, as well as modeling issues regarding control and elimination of other VPDs. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Yvette Valentine
ybt0@cdc.gov Email:ybt0@cdc.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
Folder 330329 Full Announcement-FULL_ANNOUNCEMENT -> CDC-RFA-GH21-2101.pdf
Packages
| Agency Contact Information: | Yvette Valentine ybt0@cdc.gov Email: ybt0@cdc.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.185 | CDC-RFA-GH21-2101 | Support of Global Polio Eradication Initiative (GPEI) using Integrated Modeling | PKG00264465 | Dec 11, 2020 | Feb 11, 2021 | View |
Package 1
Mandatory forms
330329 SF424_3_0-3.0.pdf
330329 Project_AbstractSummary_2_0-2.0.pdf
330329 SFLLL_2_0-2.0.pdf
330329 SF424A-1.0.pdf
330329 BudgetNarrativeAttachments_1_2-1.2.pdf
330329 ProjectNarrativeAttachments_1_2-1.2.pdf
330329 HHS_CheckList_4_0-4.0.pdf
Optional forms
330329 OtherNarrativeAttachments_1_2-1.2.pdf
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