This CDC grant is for exploring early development in individuals with autism spectrum disorder (ASD) from childhood through early adulthood. It aims to advance knowledge of ASD risk factors and expression to improve health and functioning. The work involves analyzing existing data and biospecimens from the CDC-funded Study to Explore Early Development (SEED), a multi-phase study of children with ASD or other developmental disabilities. It also supports longitudinal follow-up of SEED participants, covering epidemiologic research, intellectual assessments, maternal auto-antibody testing, genetic analyses, and biorepository maintenance.
Opportunity ID: 327720
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Sep 03, 2020 |
| Last Updated Date: | Oct 15, 2020 |
| Original Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Current Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,370,000 |
| Award Ceiling: | $1,560,000 |
| Award Floor: | $230,000 |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered for Component A, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process.Component A: Access to SEED 1-3 ParticipantsAll applicants must document that they will have access to SEED participant’s individual contact and eligibility data (i.e., status on completion of the maternal interview and clinic visit, and consent for follow-up) for all cohorts they propose to include in their recruitment pool (1, 2, and/or 3) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO.Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301(d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies.Therefore, applicants must either:1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies;OR2) have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO.The following entities have been funded by CDC to collect data for SEED: 1) JFK Partners and University of Colorado School of Medicine, Anschutz Medical Campus (SEED 1-3); 2) Johns Hopkins University and Kennedy Krieger Institute (SEED 1-3); 3) Washington University (SEED 3); 4) University of North Carolina at Chapel Hill (SEED 1-3); 5) The Board of Regents at the University of Wisconsin System (SEED 3); 6) Kaiser Permanente Division of Research and the California Department of Health Services (SEED 1-2); and 7) University of Pennsylvania School of Nursing and The Children’s Hospital of Pennsylvania (SEED 1-2).To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families.These activities will be accomplished through five components (A-E):Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED ParticipantsTo conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to:Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; andSupport the implementation of follow-up surveys in collaboration with CDC from an existing list of SEED participants in SEED 1-3.Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A.Component C: Maternal Auto-Antibody Testing To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component C, applicants must apply and be funded for Component A.Component D: Genetic Analyses To identify analytic priorities for generating and analyzing SEED genetic data; to develop and implement methods for combining existing SEED 1 genetic data and newly generated SEED 2 and 3 genetic data for use by SEED investigators and contribution to data repositories; and to support SEED investigators conducting analyses to increase understanding of the genetic risk factors for ASD and their interaction with environmental risk factors. To be funded for Component D, applicants must apply and be funded for Component A.Component E: Biorepository To maintain a repository of biospecimens previously collected from SEED 1-3 participants. To be funded for Component E, applicants must apply and be funded for Component A.Applicants should clearly indicate the components for which they are applying and should include, at the beginning of the title, the respective component under which the application should be considered (i.e., Component A, B, C, D, and/or E). A separate application is required for each component. |
| Link to Additional Information: | . |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Natalie Darling
NDH6@cdc.gov Email:NDH6@cdc.gov |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Updated the application package with the revised Version forms. | Oct 15, 2020 | |
| Updated the application package with the revised Version forms. | Sep 03, 2020 | |
| Sep 03, 2020 | ||
| Updated language for component. | Jun 16, 2020 | |
| Updated language for component. | Jun 16, 2020 | |
| Updated language for component. | Jun 16, 2020 | |
| Jun 16, 2020 |
DISPLAYING: Synopsis 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 3 |
| Posted Date: | Sep 03, 2020 |
| Last Updated Date: | Oct 15, 2020 |
| Original Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Current Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,370,000 |
| Award Ceiling: | $1,560,000 |
| Award Floor: | $230,000 |
Eligibility
| Eligible Applicants: | Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered for Component A, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process.Component A: Access to SEED 1-3 ParticipantsAll applicants must document that they will have access to SEED participant’s individual contact and eligibility data (i.e., status on completion of the maternal interview and clinic visit, and consent for follow-up) for all cohorts they propose to include in their recruitment pool (1, 2, and/or 3) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO.Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301(d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies.Therefore, applicants must either:1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies;OR2) have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO.The following entities have been funded by CDC to collect data for SEED: 1) JFK Partners and University of Colorado School of Medicine, Anschutz Medical Campus (SEED 1-3); 2) Johns Hopkins University and Kennedy Krieger Institute (SEED 1-3); 3) Washington University (SEED 3); 4) University of North Carolina at Chapel Hill (SEED 1-3); 5) The Board of Regents at the University of Wisconsin System (SEED 3); 6) Kaiser Permanente Division of Research and the California Department of Health Services (SEED 1-2); and 7) University of Pennsylvania School of Nursing and The Children’s Hospital of Pennsylvania (SEED 1-2).To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families.These activities will be accomplished through five components (A-E):Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED ParticipantsTo conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to:Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; andSupport the implementation of follow-up surveys in collaboration with CDC from an existing list of SEED participants in SEED 1-3.Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A.Component C: Maternal Auto-Antibody Testing To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component C, applicants must apply and be funded for Component A.Component D: Genetic Analyses To identify analytic priorities for generating and analyzing SEED genetic data; to develop and implement methods for combining existing SEED 1 genetic data and newly generated SEED 2 and 3 genetic data for use by SEED investigators and contribution to data repositories; and to support SEED investigators conducting analyses to increase understanding of the genetic risk factors for ASD and their interaction with environmental risk factors. To be funded for Component D, applicants must apply and be funded for Component A.Component E: Biorepository To maintain a repository of biospecimens previously collected from SEED 1-3 participants. To be funded for Component E, applicants must apply and be funded for Component A.Applicants should clearly indicate the components for which they are applying and should include, at the beginning of the title, the respective component under which the application should be considered (i.e., Component A, B, C, D, and/or E). A separate application is required for each component. |
| Link to Additional Information: | . |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Natalie Darling
NDH6@cdc.gov Email:NDH6@cdc.gov |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Sep 03, 2020 |
| Last Updated Date: | Oct 15, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,370,000 |
| Award Ceiling: | $1,560,000 |
| Award Floor: | $230,000 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered for Component A, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process.Component A: Access to SEED 1-3 ParticipantsAll applicants must document that they will have access to SEED participant’s individual contact and eligibility data (i.e., status on completion of the maternal interview and clinic visit, and consent for follow-up) for all cohorts they propose to include in their recruitment pool (1, 2, and/or 3) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO.Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301(d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies.Therefore, applicants must either:1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies;OR2) have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO.The following entities have been funded by CDC to collect data for SEED: 1) JFK Partners and University of Colorado School of Medicine, Anschutz Medical Campus (SEED 1-3); 2) Johns Hopkins University and Kennedy Krieger Institute (SEED 1-3); 3) Washington University (SEED 3); 4) University of North Carolina at Chapel Hill (SEED 1-3); 5) The Board of Regents at the University of Wisconsin System (SEED 3); 6) Kaiser Permanente Division of Research and the California Department of Health Services (SEED 1-2); and 7) University of Pennsylvania School of Nursing and The Children’s Hospital of Pennsylvania (SEED 1-2).To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families.These activities will be accomplished through five components (A-E):Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED ParticipantsTo conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to:Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; andSupport the implementation of follow-up surveys in collaboration with CDC from an existing list of SEED participants in SEED 1-3.Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A.Component C: Maternal Auto-Antibody Testing To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component C, applicants must apply and be funded for Component A.Component D: Genetic Analyses To identify analytic priorities for generating and analyzing SEED genetic data; to develop and implement methods for combining existing SEED 1 genetic data and newly generated SEED 2 and 3 genetic data for use by SEED investigators and contribution to data repositories; and to support SEED investigators conducting analyses to increase understanding of the genetic risk factors for ASD and their interaction with environmental risk factors. To be funded for Component D, applicants must apply and be funded for Component A.Component E: Biorepository To maintain a repository of biospecimens previously collected from SEED 1-3 participants. To be funded for Component E, applicants must apply and be funded for Component A.Applicants should clearly indicate the components for which they are applying and should include, at the beginning of the title, the respective component under which the application should be considered (i.e., Component A, B, C, D, and/or E). A separate application is required for each component. |
| Link to Additional Information: | . |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Natalie Darling
NDH6@cdc.gov Email:NDH6@cdc.gov |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Sep 03, 2020 |
| Last Updated Date: | Sep 03, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | Nov 10, 2020 Electronically submitted applications must be submitted no later than 5:00 p.m., ET, on the listed application due date. |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,370,000 |
| Award Ceiling: | $1,560,000 |
| Award Floor: | $230,000 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered for Component A, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process. Component A: Access to SEED 1-3 Participants All applicants must document that they will have access to SEED participant’s individual contact and eligibility data (i.e., status on completion of the maternal interview and clinic visit, and consent for follow-up) for all cohorts they propose to include in their recruitment pool (1, 2, and/or 3) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO. Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301(d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies. Therefore, applicants must either: 1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies; OR 2) have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO. The following entities have been funded by CDC to collect data for SEED: 1) JFK Partners and University of Colorado School of Medicine, Anschutz Medical Campus (SEED 1-3); 2) Johns Hopkins University and Kennedy Krieger Institute (SEED 1-3); 3) Washington University (SEED 3); 4) University of North Carolina at Chapel Hill (SEED 1-3); 5) The Board of Regents at the University of Wisconsin System (SEED 3); 6) Kaiser Permanente Division of Research and the California Department of Health Services (SEED 1-2); and 7) University of Pennsylvania School of Nursing and The Children’s Hospital of Pennsylvania (SEED 1-2). To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families. These activities will be accomplished through five components (A-E): Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED Participants To conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to: Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; and Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A. |
| Link to Additional Information: | . |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
Natalie Darling
NDH6@cdc.gov Email:NDH6@cdc.gov |
DISPLAYING: Forecast 4
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 4 |
| Posted Date: | Jun 16, 2020 |
| Last Updated Date: | Sep 03, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,520,000 |
| Award Ceiling: | $1,340,000 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process.Access to SEED 1-3 Participants:All applicants must document that they will have access to SEED 1-3 participant’s individual contact and eligibility data (i.e., status on completion of the SEED 1-3 maternal interview and clinic visit, and consent for follow-up) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO.Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301 (d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies. Therefore, applicants must either:1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies; or2) they must have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO.It is acceptable to develop an agreement whereby the PI and/or limited key personnel from former SEED 1-3 awardees are added as investigators to the applicant’s research protocol and thereby obtain rights to access the necessary personal contact information to contact former SEED participants.To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families.These activities will be accomplished through five components (A-E):Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED ParticipantsTo conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to:Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; andSupport the implementation of follow-up surveys in collaboration with CDC from an existing list of SEED participants in SEED 1-3.Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A.Component C: Maternal Auto-Antibody Testing To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component C, applicants must apply and be funded for Component A.Component D: Genetic Analyses To identify analytic priorities for generating and analyzing SEED genetic data; to develop and implement methods for combining existing SEED 1 genetic data and newly generated SEED 2 and 3 genetic data for use by SEED investigators and contribution to data repositories; and to support SEED investigators conducting analyses to increase understanding of the genetic risk factors for ASD and their interaction with environmental risk factors. To be funded for Component D, applicants must apply and be funded for Component A.Component E: Biorepository To maintain a repository of biospecimens previously collected from SEED 1-3 participants. To be funded for Component E, applicants must apply and be funded for Component A.Applicants should clearly indicate the components for which they are applying and should include, at the beginning of the title, the respective component under which the application should be considered (i.e., Component A, B, C, D, and/or E). A separate application is required for each component. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:NDH6@cdc.gov |
DISPLAYING: Forecast 3
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow-up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 3 |
| Posted Date: | Jun 16, 2020 |
| Last Updated Date: | Jun 18, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | Dec 10, 2020 |
| Estimated Total Program Funding: | $16,520,000 |
| Award Ceiling: | $1,340,000 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | For an application to be considered, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process. Access to SEED 1-3 Participants: All applicants must document that they will have access to SEED 1-3 participant’s individual contact and eligibility data (i.e., status on completion of the SEED 1-3 maternal interview and clinic visit, and consent for follow-up) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO. Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301 (d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies. Therefore, applicants must either: 1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies; or 2) they must have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO. It is acceptable to develop an agreement whereby the PI and/or limited key personnel from former SEED 1-3 awardees are added as investigators to the applicant’s research protocol and thereby obtain rights to access the necessary personal contact information to contact former SEED participants. To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families. These activities will be accomplished through five components (A-E): Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED Participants To conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to: Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; and Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component B, applicants must apply and be funded for Component A. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:NDH6@cdc.gov |
DISPLAYING: Forecast 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow-up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 2 |
| Posted Date: | Jun 16, 2020 |
| Last Updated Date: | Jun 18, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | – |
| Estimated Total Program Funding: | $16,520,000 |
| Award Ceiling: | $1,680,000 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Access to SEED 1-3 Participants:All applicants must document that they will have access to SEED 1-3 participant’s individual contact and eligibility data (i.e., status on completion of the SEED 1-3 maternal interview and clinic visit, and consent for follow-up) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO.Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301 (d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies. Therefore, applicants must either:1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies; or2) they must have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO.It is acceptable to develop an agreement whereby the PI and limited key personnel from former SEED 1-3 awardees are added as investigators to the applicant’s research protocol and thereby obtain rights to access the necessary personal contact information to contact former SEED participants.To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families.These activities will be accomplished through five components (A-E):Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED ParticipantsTo conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to:Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; andSupport the implementation of follow-up surveys in collaboration with CDC from an existing list of SEED participants in SEED 1-3.Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component B, applicants must apply and be funded for Component A.Component C: Maternal Auto-Antibody Testing To conduct follow-up assessments of intellectual abilities on a subset of children and adolescents (aged ≥ 8 years), who were initially identified as having ASD or another DD in SEED 1-3 and who completed the follow-up surveys implemented through Component A of this NOFO. To be funded for Component C, applicants must apply and be funded for Component A.Component D: Genetic Analyses To identify analytic priorities for generating and analyzing SEED genetic data; to develop and implement methods for combining existing SEED 1 genetic data and newly generated SEED 2 and 3 genetic data for use by SEED investigators and contribution to data repositories; and to support SEED investigators conducting analyses to increase understanding of the genetic risk factors for ASD and their interaction with environmental risk factors. To be funded for Component D, applicants must apply and be funded for Component A.Component E: Biorepository To maintain a repository of biospecimens previously collected from SEED 1-3 participants. To be funded for Component E, applicants must apply and be funded for Component A.Applicants should clearly indicate the components for which they are applying and should include, at the beginning of the title, the respective component under which the application should be considered (i.e., Component A, B, C, D, and/or E). A separate application is required for each component. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:NDH6@cdc.gov |
DISPLAYING: Forecast 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DD-21-001 |
| Funding Opportunity Title: | Study to Explore Early Development (SEED) Follow-up Studies |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | 11 |
| Assistance Listings: | 93.073 — Birth Defects and Developmental Disabilities – Prevention and Surveillance |
| Cost Sharing or Matching Requirement: | No |
| Version: | Forecast 1 |
| Posted Date: | Jun 16, 2020 |
| Last Updated Date: | Jun 16, 2020 |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – |
| Archive Date: | – |
| Estimated Total Program Funding: | $16,520,000 |
| Award Ceiling: | $1,680,000 |
| Award Floor: | $0 |
Eligibility
| Eligible Applicants: | Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Special district governments For profit organizations other than small businesses City or township governments Independent school districts State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Access to SEED 1-3 Participants: All applicants must document that they will have access to SEED 1-3 participant’s individual contact and eligibility data (i.e., status on completion of the SEED 1-3 maternal interview and clinic visit, and consent for follow-up) to ensure successful completion of the SEED follow-up studies outlined in Component A of the NOFO. Data for SEED 1-3 were collected under a Certificate of Confidentiality in accordance with section 301 (d) of the Public Health Service Act. SEED 1-3 participants were provided assurances that only those entities that originally collected their personal information would use this information to contact them for future studies. Therefore, applicants must either: 1) be the original entities that collected the original SEED data on children 2-5 years of age and their parents, and therefore have the information needed to reach these individuals for the follow-up studies; or 2) they must have established collaborative agreements to work with the entities that originally collected contact information from SEED participants (i.e., former SEED awardees) so that they can reach the SEED participants for the follow-up studies as outlined in this NOFO. It is acceptable to develop an agreement whereby the PI and limited key personnel from former SEED 1-3 awardees are added as investigators to the applicant’s research protocol and thereby obtain rights to access the necessary personal contact information to contact former SEED participants. To be funded for Component B, C, D, or E, applicants must apply and be funded for Component A. |
Additional Information
| Agency Name: | Centers for Disease Control and Prevention – ERA |
| Description: | The purpose of this NOFO is to gain knowledge about autism spectrum disorder (ASD), including risk factors for ASD and the expression of ASD, from childhood through early adulthood, and to obtain information that can be used to improve the health and functioning of individuals with ASD as they mature. This will be completed through 1) analysis of existing data and biospecimens from preschool-aged children and their families who participated in the CDC funded study known as the Study to Explore Early Development (SEED), a multi-phase, multi-site, case-control study of children identified at age 2-5 years with ASD, other developmental disabilities (DD), and from the general population (POP); and 2) longitudinal follow-up of and research on previous SEED participants to obtain information through early adulthood on their health and functioning, service use and needs, and the impact of ASD on their families. These activities will be accomplished through five components (A-E): Component A: Enhanced Epidemiologic Research Using Existing SEED Data Follow-up Surveys of Existing SEED Participants To conduct analyses of existing SEED data and follow-up surveys of participants from SEED Phases 1, 2, and 3 (referred to as SEED 1-3) to: Address current research gaps, and publish findings related to risk factors for ASD and the characteristics and needs of children with ASD; and Component B: In-Person Assessment of Intellectual Abilities of SEED Participants To conduct assays of maternal autoantibodies reactive to proteins in the fetal brain using stored SEED 1 and 2 samples and to conduct analyses of the association between these maternal autoantibodies and ASD. To be funded for Component B, applicants must apply and be funded for Component A. |
| Link to Additional Information: | – |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
–
Email:NDH6@cdc.gov |
Related Documents
Folder 327720 Revised Full Announcement-REVISED_FULL_ANNOUNCEMENT -> DD-21-001 Amendment 1.pdf
Folder 327720 Revised Full Announcement-REVISED_FULL_ANNOUNCEMENT -> RFA-DD-21-001.pdf
Packages
| Agency Contact Information: | Natalie Darling NDH6@cdc.gov Email: NDH6@cdc.gov |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.073 | RFA-DD-21-001 | Study to Explore Early Development (SEED) Follow up Studies | PKG00263230 | Sep 03, 2020 | Nov 10, 2020 | View |
Package 1
Mandatory forms
327720 RR_SF424_2_0-2.0.pdf
327720 RR_Budget_1_4-1.4.pdf
327720 PHS398_ResearchPlan_4_0-4.0.pdf
327720 PHS398_CoverPageSupplement_5_0-5.0.pdf
327720 RR_OtherProjectInfo_1_4-1.4.pdf
327720 PerformanceSite_2_0-2.0.pdf
327720 RR_KeyPersonExpanded_2_0-2.0.pdf
327720 PHSHumanSubjectsAndClinicalTrialsInfo_2_0-2.0.pdf
Optional forms
327720 RR_SubawardBudget30_1_4-1.4.pdf
Share This Post, Choose Your Platform!
About the Author: osnqt
