DARPA is offering a grant for innovative research to produce a recombinant butyrylcholinesterase (rBuChE) using Nicotiana benthamiana plants. The goal is to create a plant-based form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents, matching the pharmacokinetic profile of human butyrylcholinesterase. This funding opportunity is for basic research to establish the technical feasibility of using plant platforms for this purpose. The grant period is 12 months, aiming to advance biotechnology in defense against chemical threats.
Opportunity ID: 144634
General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | DARPA-BAA-12-31 |
| Funding Opportunity Title:: | Butyrylcholinesterase Expression in Plants |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Science and Technology and other Research and Development |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 12.910 — Research and Technology Development |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 3 |
| Posted Date:: | Feb 16, 2012 |
| Last Updated Date:: | Mar 21, 2012 |
| Original Closing Date for Applications:: | Apr 26, 2012 |
| Current Closing Date for Applications:: | May 17, 2012 |
| Archive Date:: | Jul 17, 2012 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $ |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility” |
| Additional Information on Eligibility:: |
Additional Information
| Agency Name:: | DARPA – Defense Sciences Office |
| Description:: | DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 3 | Modification 2 to DARPA-BAA-12-31 is to extend the Closing Date for full proposals. See attachment DARPA-BAA-12-31 | Mar 21, 2012 |
| Synopsis 2 | Modification 1 to DARPA-BAA-12-31 is to revise DARPA’s mailing address. See attached Modification 1 for details. | |
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | 12.910 |
| Competition ID: | |
| Competition Title: | |
| Opportunity Package ID: | PKG00098072 |
| Opening Date: | Feb 16, 2012 |
| Closing Date: | May 17, 2012 |
| Agency Contact Information:: | BAA Coordinator |
| Who Can Apply:: | Organization and Individual Applicants |
| mendatory_forms | SF424 (R & R) [V1.1] |
| optional_forms |
Disclosure of Lobbying Activities (SF-LLL) [V1.1] Research & Related Budget (Total Fed + Non-Fed) [V1.1] Research & Related Subaward Budget (Total Fed + Non-Fed) Attachment(s) Form [V1.2] Research & Related Other Project Information [V1.1] Research & Related Budget [V1.1] Research & Related Senior/Key Person Profile (Expanded) [V1.1] Research & Related Project/Performance Site Location(s) [V1.1] R & R Subaward Budget Attachment(s) Form [V1.2] Research & Related Senior/Key Person Profile [V1.1] Attachments [V1.1] |
Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| 12.910 | PKG00098072 | Feb 16, 2012 | May 17, 2012 | View | BAA Coordinator | Organization and Individual Applicants |